tetano
Editor, Senior Moderator
PLoS Pathog
. 2020 Jun 22;16(6):e1008570.
doi: 10.1371/journal.ppat.1008570. eCollection 2020 Jun.
Biological Sex Impacts COVID-19 Outcomes
Sabra L Klein[SUP] 1 2 [/SUP], Santosh Dhakal[SUP] 1 [/SUP], Rebecca L Ursin[SUP] 2 [/SUP], Sharvari Deshpande[SUP] 1 [/SUP], Kathryn Sandberg[SUP] 3 [/SUP], Franck Mauvais-Jarvis[SUP] 4 5 [/SUP]
Affiliations
Abstract
The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.
. 2020 Jun 22;16(6):e1008570.
doi: 10.1371/journal.ppat.1008570. eCollection 2020 Jun.
Biological Sex Impacts COVID-19 Outcomes
Sabra L Klein[SUP] 1 2 [/SUP], Santosh Dhakal[SUP] 1 [/SUP], Rebecca L Ursin[SUP] 2 [/SUP], Sharvari Deshpande[SUP] 1 [/SUP], Kathryn Sandberg[SUP] 3 [/SUP], Franck Mauvais-Jarvis[SUP] 4 5 [/SUP]
Affiliations
- PMID: 32569293
- DOI: 10.1371/journal.ppat.1008570
Abstract
The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.