tetano
Editor, Senior Moderator
PLoS Pathog
. 2020 Sep 18;16(9):e1008874.
doi: 10.1371/journal.ppat.1008874. eCollection 2020 Sep.
Exploring links between vitamin D deficiency and COVID-19
Mradul Mohan[SUP] 1 [/SUP], Jerin Jose Cherian[SUP] 2 [/SUP], Amit Sharma[SUP] 1 3 [/SUP]
Affiliations
Abstract
Coronavirus Disease 2019 (COVID-19) pandemic remains a major public health threat in most countries. The causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to acute respiratory distress syndrome and result in mortality in COVID-19 patients. Vitamin D is an immunomodulator hormone with established effectiveness against various upper respiratory infections. Vitamin D can stall hyper-inflammatory responses and expedite healing process of the affected areas, primarily in the lung tissue. Thus, there are ecological and mechanistic reasons to promote exploration of vitamin D action in COVID-19 patients. As no curative drugs are available currently for COVID-19, we feel that the potential of vitamin D to alter the course of disease severity needs to be investigated. Clinical studies may be undertaken to address the value of vitamin D supplementation in deficient, high-risk COVID-19 patients.
. 2020 Sep 18;16(9):e1008874.
doi: 10.1371/journal.ppat.1008874. eCollection 2020 Sep.
Exploring links between vitamin D deficiency and COVID-19
Mradul Mohan[SUP] 1 [/SUP], Jerin Jose Cherian[SUP] 2 [/SUP], Amit Sharma[SUP] 1 3 [/SUP]
Affiliations
- PMID: 32946517
- DOI: 10.1371/journal.ppat.1008874
Abstract
Coronavirus Disease 2019 (COVID-19) pandemic remains a major public health threat in most countries. The causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to acute respiratory distress syndrome and result in mortality in COVID-19 patients. Vitamin D is an immunomodulator hormone with established effectiveness against various upper respiratory infections. Vitamin D can stall hyper-inflammatory responses and expedite healing process of the affected areas, primarily in the lung tissue. Thus, there are ecological and mechanistic reasons to promote exploration of vitamin D action in COVID-19 patients. As no curative drugs are available currently for COVID-19, we feel that the potential of vitamin D to alter the course of disease severity needs to be investigated. Clinical studies may be undertaken to address the value of vitamin D supplementation in deficient, high-risk COVID-19 patients.