Giuseppe
Emeritus
Pathogenesis of the 1918 Pandemic Influenza Virus (PLoS Pathogens, extract, edited)
[Source: PLoS Pathogens, full text: <cite cite="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1001218?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+plospathogens%2FNewArticles+%28Ambra+-+Pathogens+New+Articles%29">PLoS Pathogens: Pathogenesis of the 1918 Pandemic Influenza Virus</cite>. Extract, edited.]
Pathogenesis of the 1918 Pandemic Influenza Virus
Tokiko Watanabe 1,2*, Yoshihiro Kawaoka 1,2,3,4,5*
1 Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America,
2 ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan,
3 Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan,
4 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan,
5 International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Citation: Watanabe T, Kawaoka Y (2011) Pathogenesis of the 1918 Pandemic Influenza Virus. PLoS Pathog 7(1): e1001218. doi:10.1371/journal.ppat.1001218
Editor: Hiten D. Madhani, University of California San Francisco, United States of America
Published: January 27, 2011
Copyright: ? 2011 Watanabe, Kawaoka.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported, in part, by U.S. National Institute of Allergy and Infectious Diseases Public Health Service research grants, by a grant-in-aid for Specially Promoted Research (Japan), by funding from the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology (Japan), and by ERATO (Japan Science and Technology Agency). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: twatanabe@svm.vetmed.wisc.edu (TW); kawaokay@svm.vetmed.wisc.edu (YK)
At the height of World War I, the human population was assaulted by a powerful, but very small, foreign agent that rapidly appeared seemingly from nowhere. Ultimately identified as the ?Spanish flu?, this agent wreaked havoc on anyone in its path. Prostrating vast numbers of victims worldwide with severe pneumonia, which often progressed to a fatal outcome, the ?Spanish flu? caused an estimated 20?50 million deaths worldwide [1]. The resultant 1918 pandemic was one of the most formidable foes faced by humankind. In this brief review, we discuss some recent insights into the pathogenicity of its causative agent, the 1918 pandemic influenza virus.
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------<cite cite="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1001218?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+plospathogens%2FNewArticles+%28Ambra+-+Pathogens+New+Articles%29"></cite>
[Source: PLoS Pathogens, full text: <cite cite="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1001218?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+plospathogens%2FNewArticles+%28Ambra+-+Pathogens+New+Articles%29">PLoS Pathogens: Pathogenesis of the 1918 Pandemic Influenza Virus</cite>. Extract, edited.]
Pathogenesis of the 1918 Pandemic Influenza Virus
Tokiko Watanabe 1,2*, Yoshihiro Kawaoka 1,2,3,4,5*
1 Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America,
2 ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan,
3 Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan,
4 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan,
5 International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Citation: Watanabe T, Kawaoka Y (2011) Pathogenesis of the 1918 Pandemic Influenza Virus. PLoS Pathog 7(1): e1001218. doi:10.1371/journal.ppat.1001218
Editor: Hiten D. Madhani, University of California San Francisco, United States of America
Published: January 27, 2011
Copyright: ? 2011 Watanabe, Kawaoka.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported, in part, by U.S. National Institute of Allergy and Infectious Diseases Public Health Service research grants, by a grant-in-aid for Specially Promoted Research (Japan), by funding from the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology (Japan), and by ERATO (Japan Science and Technology Agency). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: twatanabe@svm.vetmed.wisc.edu (TW); kawaokay@svm.vetmed.wisc.edu (YK)
At the height of World War I, the human population was assaulted by a powerful, but very small, foreign agent that rapidly appeared seemingly from nowhere. Ultimately identified as the ?Spanish flu?, this agent wreaked havoc on anyone in its path. Prostrating vast numbers of victims worldwide with severe pneumonia, which often progressed to a fatal outcome, the ?Spanish flu? caused an estimated 20?50 million deaths worldwide [1]. The resultant 1918 pandemic was one of the most formidable foes faced by humankind. In this brief review, we discuss some recent insights into the pathogenicity of its causative agent, the 1918 pandemic influenza virus.
(...)
-
------<cite cite="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1001218?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+plospathogens%2FNewArticles+%28Ambra+-+Pathogens+New+Articles%29"></cite>