PLoS - Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae

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[h=1]Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae[/h]

• Eleanor R. Watkins,
• Bridget S. Penman,
• Jos? Louren?o,
• Caroline O. Buckee,
• Martin C. J. Maiden,
• Sunetra Gupta

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• Published: July 16, 2015
• DOI: 10.1371/journal.ppat.1005034

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[h=2]Abstract[/h] The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS).


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http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005034