tetano
Editor, Senior Moderator
Epidemiol Infect. 2015 Mar 12:1-6. [Epub ahead of print]
[h=1]Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.[/h] Hoa LN[SUP]1[/SUP], Bryant JE[SUP]1[/SUP], Choisy M[SUP]1[/SUP], Nguyet LA[SUP]1[/SUP], Bao NT[SUP]1[/SUP], Trang NH[SUP]1[/SUP], Chuc NT[SUP]2[/SUP], Toan TK[SUP]2[/SUP], Saito T[SUP]3[/SUP], Takemae N[SUP]3[/SUP], Horby P[SUP]1[/SUP], Wertheim H[SUP]1[/SUP], Fox A[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62?6% [95% confidence interval (CI) 59?4-65?7] against A/Perth/16/2009 and 54?6% (95% CI 51?4-57?8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
[h=4]KEYWORDS:[/h] zoonoses
PMID: 25761949 [PubMed - as supplied by publisher]
[h=1]Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.[/h] Hoa LN[SUP]1[/SUP], Bryant JE[SUP]1[/SUP], Choisy M[SUP]1[/SUP], Nguyet LA[SUP]1[/SUP], Bao NT[SUP]1[/SUP], Trang NH[SUP]1[/SUP], Chuc NT[SUP]2[/SUP], Toan TK[SUP]2[/SUP], Saito T[SUP]3[/SUP], Takemae N[SUP]3[/SUP], Horby P[SUP]1[/SUP], Wertheim H[SUP]1[/SUP], Fox A[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62?6% [95% confidence interval (CI) 59?4-65?7] against A/Perth/16/2009 and 54?6% (95% CI 51?4-57?8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
[h=4]KEYWORDS:[/h] zoonoses
PMID: 25761949 [PubMed - as supplied by publisher]