Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine

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Clin Infect Dis. 2019 Aug 11. pii: ciz723. doi: 10.1093/cid/ciz723. [Epub ahead of print]
[h=1]Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine.[/h] Gouma S[SUP]1[/SUP], Weirick M[SUP]1[/SUP], Hensley SE[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

[h=3]Abstract[/h] Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic since most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.


[h=4]KEYWORDS:[/h] H3N2; Influenza virus; hemagglutinin; influenza vaccine

PMID: 31400756 DOI: 10.1093/cid/ciz723