tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2010 Sep 28. [Epub ahead of print]
Pre-existing Antibody Response against 2009 Pandemic Influenza H1N1 Viruses in Taiwanese Population.
Chi CY, Liu CC, Lin CC, Wang HC, Cheng YT, Chang CM, Wang JR.
Division of Infectious Diseases, National Health Research Institutes, Tainan, Taiwan; Departments of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan; Departments of Pediatric and Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Abstract
Novel pandemic influenza H1N1 (pH1N1) virus spread rapidly across the world in 2009. Due to the important role of the antibody-mediated immunity in the protection of influenza infection, we investigated the cross-reactive neutralizing antibodies against 2009 pH1N1 of 229 stored sera from donors born between 1917 and 2008 in Taiwan using enzyme-linked immunosorbent assay-based microneutralization test. The peak of cumulative geometric mean titer was in donors aged over 90 years and declined sharply afterward. Sixteen of 27 subjects (59%) aged over 80 years had cross-reactive antibody titer of 160 or more against the 2009 pH1N1, whereas none of the donors from age 9 to 49 had an antibody titer of 160 or more. Interestingly, 2 of 51 children (4%) ranging in 6 months to 9 years old had an antibody titer of 40. We further tested the antibody response in 9 of the 51 pediatric sera to three endemic seasonal influenza viruses isolated in 2006 and 2008 in Taiwan, and the results showed only the 2 sera from children with antibody responses to 2009 pH1N1 had high neutralizing antibody titer against recent seasonal influenza strains. Our study shows the presence of some level of cross-reactive antibody in Taiwanese persons 50 years or older, and the elderly subjects who may already be exposed to the 1918 virus had high neutralizing antibody titer to the 2009 pH1N1. Our data also indicate that natural infection with the Taiwan 2006 and 2008 seasonal H1N1 viruses may induce cross-reactive antibody response to 2009 pH1N1.
PMID: 20876823 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20876823
Pre-existing Antibody Response against 2009 Pandemic Influenza H1N1 Viruses in Taiwanese Population.
Chi CY, Liu CC, Lin CC, Wang HC, Cheng YT, Chang CM, Wang JR.
Division of Infectious Diseases, National Health Research Institutes, Tainan, Taiwan; Departments of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan; Departments of Pediatric and Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Abstract
Novel pandemic influenza H1N1 (pH1N1) virus spread rapidly across the world in 2009. Due to the important role of the antibody-mediated immunity in the protection of influenza infection, we investigated the cross-reactive neutralizing antibodies against 2009 pH1N1 of 229 stored sera from donors born between 1917 and 2008 in Taiwan using enzyme-linked immunosorbent assay-based microneutralization test. The peak of cumulative geometric mean titer was in donors aged over 90 years and declined sharply afterward. Sixteen of 27 subjects (59%) aged over 80 years had cross-reactive antibody titer of 160 or more against the 2009 pH1N1, whereas none of the donors from age 9 to 49 had an antibody titer of 160 or more. Interestingly, 2 of 51 children (4%) ranging in 6 months to 9 years old had an antibody titer of 40. We further tested the antibody response in 9 of the 51 pediatric sera to three endemic seasonal influenza viruses isolated in 2006 and 2008 in Taiwan, and the results showed only the 2 sera from children with antibody responses to 2009 pH1N1 had high neutralizing antibody titer against recent seasonal influenza strains. Our study shows the presence of some level of cross-reactive antibody in Taiwanese persons 50 years or older, and the elderly subjects who may already be exposed to the 1918 virus had high neutralizing antibody titer to the 2009 pH1N1. Our data also indicate that natural infection with the Taiwan 2006 and 2008 seasonal H1N1 viruses may induce cross-reactive antibody response to 2009 pH1N1.
PMID: 20876823 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20876823