tetano
Editor, Senior Moderator
Benef Microbes. 2019 Feb 18:1-14. doi: 10.3920/BM2018.0098. [Epub ahead of print]
[h=1]Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses.[/h] van den Elsen LWJ[SUP]1[/SUP], Tims S[SUP]1[/SUP], Jones AM[SUP]1[/SUP], Stewart A[SUP]1[/SUP], Stahl B[SUP]2[/SUP], Garssen J[SUP]2,[/SUP][SUP]3[/SUP], Knol J[SUP]2,[/SUP][SUP]4[/SUP], Forbes-Blom EE[SUP]1[/SUP], Van't Land B[SUP]2,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Beneficial modulation of the gut microbiota is an attractive therapeutic approach to improve the efficacy of vaccine-induced immunity. In this study, mice were supplemented with the prebiotic milk oligosaccharide 2'-fucosyllactose (2'FL) as well as a complex mixture of immune modulatory prebiotic short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) from different stages in early life. Adult mice were vaccinated with trivalent influenza vaccine (TIV) and both development of the gut microbiota and antibody-mediated vaccine responses were followed over time. Within the control group, female mice demonstrated a larger antibody response to TIV vaccination than male mice, which was accompanied by enhanced cytokine production by splenocytes and a higher percentage of plasma cells in skin draining lymph nodes. In addition, the prebiotic diet improved vaccine-specific antibody responses in male mice. Introduction of prebiotics into the diet modulated the gut microbiota composition and at the genus level several bacterial groups showed a significant interaction effect which potentially contributed to the immunological effects observed. This study provides insight in the effect of scGOS/lcFOS/2'FL in influenza vaccination antibody production.
[h=4]KEYWORDS:[/h] HMOS; TIV; antibody; gender; microbiota
PMID: 30773928 DOI: 10.3920/BM2018.0098
[h=1]Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses.[/h] van den Elsen LWJ[SUP]1[/SUP], Tims S[SUP]1[/SUP], Jones AM[SUP]1[/SUP], Stewart A[SUP]1[/SUP], Stahl B[SUP]2[/SUP], Garssen J[SUP]2,[/SUP][SUP]3[/SUP], Knol J[SUP]2,[/SUP][SUP]4[/SUP], Forbes-Blom EE[SUP]1[/SUP], Van't Land B[SUP]2,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Beneficial modulation of the gut microbiota is an attractive therapeutic approach to improve the efficacy of vaccine-induced immunity. In this study, mice were supplemented with the prebiotic milk oligosaccharide 2'-fucosyllactose (2'FL) as well as a complex mixture of immune modulatory prebiotic short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) from different stages in early life. Adult mice were vaccinated with trivalent influenza vaccine (TIV) and both development of the gut microbiota and antibody-mediated vaccine responses were followed over time. Within the control group, female mice demonstrated a larger antibody response to TIV vaccination than male mice, which was accompanied by enhanced cytokine production by splenocytes and a higher percentage of plasma cells in skin draining lymph nodes. In addition, the prebiotic diet improved vaccine-specific antibody responses in male mice. Introduction of prebiotics into the diet modulated the gut microbiota composition and at the genus level several bacterial groups showed a significant interaction effect which potentially contributed to the immunological effects observed. This study provides insight in the effect of scGOS/lcFOS/2'FL in influenza vaccination antibody production.
[h=4]KEYWORDS:[/h] HMOS; TIV; antibody; gender; microbiota
PMID: 30773928 DOI: 10.3920/BM2018.0098