tetano
Editor, Senior Moderator
Open Forum Infect Dis. 2015 Apr 15;2(2)
fv052. doi: 10.1093/ofid/ofv052. eCollection 2015.
[h=1]Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses.[/h] Reber AJ[SUP]1[/SUP], Kim JH[SUP]1[/SUP], Biber R[SUP]1[/SUP], Talbot HK[SUP]2[/SUP], Coleman LA[SUP]3[/SUP], Chirkova T[SUP]1[/SUP], Gross FL[SUP]1[/SUP], Steward-Clark E[SUP]1[/SUP], Cao W[SUP]1[/SUP], Jefferson S[SUP]1[/SUP], Veguilla V[SUP]1[/SUP], Gillis E[SUP]1[/SUP], Meece J[SUP]3[/SUP], Bai Y[SUP]1[/SUP], Tatum H[SUP]1[/SUP], Hancock K[SUP]1[/SUP], Stevens J[SUP]1[/SUP], Spencer S[SUP]1[/SUP], Chen J[SUP]1[/SUP], Gargiullo P[SUP]1[/SUP], Braun E[SUP]1[/SUP], Griffin MR[SUP]4[/SUP], Sundaram M[SUP]3[/SUP], Belongia EA[SUP]3[/SUP], Shay DK[SUP]1[/SUP], Katz JM[SUP]1[/SUP], Sambhara S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background. Influenza disproportionately impacts older adults while current vaccines have reduced effectiveness in the older population. Methods. We conducted a comprehensive evaluation of cellular and humoral immune responses of adults aged 50 years and older to the 2008-2009 seasonal trivalent inactivated influenza vaccine and assessed factors influencing vaccine response. Results. Vaccination increased hemagglutination inhibition and neutralizing antibody; however, 66.3% of subjects did not reach hemagglutination inhibition titers ≥ 40 for H1N1, compared with 22.5% for H3N2. Increasing age had a minor negative impact on antibody responses, whereas prevaccination titers were the best predictors of postvaccination antibody levels. Preexisting memory B cells declined with age, especially for H3N2. However, older adults still demonstrated a significant increase in antigen-specific IgG(+) and IgA(+) memory B cells postvaccination. Despite reduced frequency of preexisting memory B cells associated with advanced age, fold-rise in memory B cell frequency in subjects 60+ was comparable to subjects age 50-59. Conclusions. Older adults mounted statistically significant humoral and cell-mediated immune responses, but many failed to reach hemagglutination inhibition titers ≥40, especially for H1N1. Although age had a modest negative effect on vaccine responses, prevaccination titers were the best predictor of postvaccination antibody levels, irrespective of age.
[h=4]KEYWORDS:[/h] aging; immune response; influenza; older adults; vaccine
PMID: 26380344 [PubMed]
fv052. doi: 10.1093/ofid/ofv052. eCollection 2015.[h=1]Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses.[/h] Reber AJ[SUP]1[/SUP], Kim JH[SUP]1[/SUP], Biber R[SUP]1[/SUP], Talbot HK[SUP]2[/SUP], Coleman LA[SUP]3[/SUP], Chirkova T[SUP]1[/SUP], Gross FL[SUP]1[/SUP], Steward-Clark E[SUP]1[/SUP], Cao W[SUP]1[/SUP], Jefferson S[SUP]1[/SUP], Veguilla V[SUP]1[/SUP], Gillis E[SUP]1[/SUP], Meece J[SUP]3[/SUP], Bai Y[SUP]1[/SUP], Tatum H[SUP]1[/SUP], Hancock K[SUP]1[/SUP], Stevens J[SUP]1[/SUP], Spencer S[SUP]1[/SUP], Chen J[SUP]1[/SUP], Gargiullo P[SUP]1[/SUP], Braun E[SUP]1[/SUP], Griffin MR[SUP]4[/SUP], Sundaram M[SUP]3[/SUP], Belongia EA[SUP]3[/SUP], Shay DK[SUP]1[/SUP], Katz JM[SUP]1[/SUP], Sambhara S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background. Influenza disproportionately impacts older adults while current vaccines have reduced effectiveness in the older population. Methods. We conducted a comprehensive evaluation of cellular and humoral immune responses of adults aged 50 years and older to the 2008-2009 seasonal trivalent inactivated influenza vaccine and assessed factors influencing vaccine response. Results. Vaccination increased hemagglutination inhibition and neutralizing antibody; however, 66.3% of subjects did not reach hemagglutination inhibition titers ≥ 40 for H1N1, compared with 22.5% for H3N2. Increasing age had a minor negative impact on antibody responses, whereas prevaccination titers were the best predictors of postvaccination antibody levels. Preexisting memory B cells declined with age, especially for H3N2. However, older adults still demonstrated a significant increase in antigen-specific IgG(+) and IgA(+) memory B cells postvaccination. Despite reduced frequency of preexisting memory B cells associated with advanced age, fold-rise in memory B cell frequency in subjects 60+ was comparable to subjects age 50-59. Conclusions. Older adults mounted statistically significant humoral and cell-mediated immune responses, but many failed to reach hemagglutination inhibition titers ≥40, especially for H1N1. Although age had a modest negative effect on vaccine responses, prevaccination titers were the best predictor of postvaccination antibody levels, irrespective of age.
[h=4]KEYWORDS:[/h] aging; immune response; influenza; older adults; vaccine
PMID: 26380344 [PubMed]