tetano
Editor, Senior Moderator
Am J Physiol Lung Cell Mol Physiol. 2018 May 31. doi: 10.1152/ajplung.00066.2018. [Epub ahead of print]
[h=1]Pregnancy preserves pulmonary function following influenza virus infection in C57BL/6 mice.[/h] Vermillion MS[SUP]1[/SUP], Nelson A[SUP]1[/SUP], Vom Steeg LG[SUP]1[/SUP], Loube JM[SUP]2[/SUP], Mitzner W[SUP]3[/SUP], Klein SL[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pregnancy is associated with significant anatomic and functional changes to the cardiopulmonary system. Using pregnant C57BL/6 mice, we characterized changes in pulmonary structure and function during pregnancy in healthy animals and following infection with influenza A virus (IAV). We hypothesized that pregnancy-associated alterations in pulmonary physiology would contribute to the more severe outcome of IAV infection. Nonpregnant and pregnant females (at embryonic day 10.5) were either mock-infected or infected with 2009 H1N1 IAV for assessment of pulmonary function, structure, and inflammation at 8 days post-inoculation. There were baseline differences in pulmonary function, with pregnant females having greater lung compliance, total lung capacity, and fixed lung volume than nonpregnant females. Following IAV infection, both pregnant and nonpregnant females exhibited reduced circulating progesterone, which in nonpregnant females was associated with increased pulmonary resistance and decreased lung compliance, minute ventilation, and oxygen diffusing capacity as compared with uninfected nonpregnant females. In pregnant females, reduced concentrations of progesterone were associated with adverse pregnancy outcomes, but measures of pulmonary function were preserved following IAV infection and were not significantly different from uninfected pregnant mice. Following IAV infection, infectious virus titers and total numbers of pulmonary leukocytes were similar between pregnant and nonpregnant females, but the histologic density of pulmonary inflammation was reduced in pregnant animals. These data suggest that pregnancy in mice is associated with significant alterations in pulmonary physiology, but these changes served to preserve lung function during IAV infection. Pregnancy-associated alterations in pulmonary physiology may serve to protect females during severe influenza.
[h=4]KEYWORDS:[/h] acute lung injury; progesterone; pulmonary inflammation; pulmonary structure; respiratory infection
PMID: 29847990 DOI: 10.1152/ajplung.00066.2018
[h=1]Pregnancy preserves pulmonary function following influenza virus infection in C57BL/6 mice.[/h] Vermillion MS[SUP]1[/SUP], Nelson A[SUP]1[/SUP], Vom Steeg LG[SUP]1[/SUP], Loube JM[SUP]2[/SUP], Mitzner W[SUP]3[/SUP], Klein SL[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pregnancy is associated with significant anatomic and functional changes to the cardiopulmonary system. Using pregnant C57BL/6 mice, we characterized changes in pulmonary structure and function during pregnancy in healthy animals and following infection with influenza A virus (IAV). We hypothesized that pregnancy-associated alterations in pulmonary physiology would contribute to the more severe outcome of IAV infection. Nonpregnant and pregnant females (at embryonic day 10.5) were either mock-infected or infected with 2009 H1N1 IAV for assessment of pulmonary function, structure, and inflammation at 8 days post-inoculation. There were baseline differences in pulmonary function, with pregnant females having greater lung compliance, total lung capacity, and fixed lung volume than nonpregnant females. Following IAV infection, both pregnant and nonpregnant females exhibited reduced circulating progesterone, which in nonpregnant females was associated with increased pulmonary resistance and decreased lung compliance, minute ventilation, and oxygen diffusing capacity as compared with uninfected nonpregnant females. In pregnant females, reduced concentrations of progesterone were associated with adverse pregnancy outcomes, but measures of pulmonary function were preserved following IAV infection and were not significantly different from uninfected pregnant mice. Following IAV infection, infectious virus titers and total numbers of pulmonary leukocytes were similar between pregnant and nonpregnant females, but the histologic density of pulmonary inflammation was reduced in pregnant animals. These data suggest that pregnancy in mice is associated with significant alterations in pulmonary physiology, but these changes served to preserve lung function during IAV infection. Pregnancy-associated alterations in pulmonary physiology may serve to protect females during severe influenza.
[h=4]KEYWORDS:[/h] acute lung injury; progesterone; pulmonary inflammation; pulmonary structure; respiratory infection
PMID: 29847990 DOI: 10.1152/ajplung.00066.2018