tetano
Editor, Senior Moderator
Scand J Infect Dis. 2010 Oct 6. [Epub ahead of print]
Prevalence and clinical features of pneumonia in patients with laboratory-confirmed pandemic influenza A H1N1 2009 infection in South Korea.
Na S, Kim MN, Kim WY, Kim W, Hong SB, Lim CM, Koh Y, Kwon JW, Hong SJ, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH.
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Abstract
Abstract During the early stages of the pandemic influenza A H1N1 2009 (pH1N1) outbreak in South Korea, the government recommended antiviral therapy with laboratory confirmation in specialized hospitals. Hence we had a unique opportunity to test all patients suspected to have pH1N1, including those who initially presented with a mild illness, such as those who were not in at-risk groups and who had an uncomplicated illness. We therefore evaluated the proportion and clinical features of pneumonia in patients with laboratory-confirmed pH1N1. Of the 3253 patients who visited Asan Medical Center, Seoul, South Korea, between 24 August and 19 October 2009 for a suspected pH1N1 infection (temperature ≥37.5°C and at least 1 of the following symptoms: sore throat, cough, rhinorrhoea and nasal congestion), 553 (17%) were positive for pH1N1 by real-time reverse-transcriptase polymerase chain reaction. Chest radiographs were performed in 96 (17%) of the 553 patients. Of the 553 patients, 30 (5%; 95% confidence interval (CI) 4–8%) had pneumonia, including 26 (86%) with viral pneumonia and 4 (14%) with bacterial pneumonia. So, the proportion of pneumonia in patients with laboratory-confirmed pH1N1 was at least 5%. Multivariate analysis indicated that dyspnoea (odds ratio (OR) 57.8, p < 0.001), wheezing (OR 19.3, p = 0.02), vomiting (OR 18.5, p < 0.001) and diarrhoea (OR 11.0, p = 0.001) were independently associated with pneumonia. Antiviral therapy at >48 h after the onset of symptoms (OR 2.1, p = 0.09) tended to be more common in patients with pneumonia than in those without pneumonia.
PMID: 20925450 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20925450
Prevalence and clinical features of pneumonia in patients with laboratory-confirmed pandemic influenza A H1N1 2009 infection in South Korea.
Na S, Kim MN, Kim WY, Kim W, Hong SB, Lim CM, Koh Y, Kwon JW, Hong SJ, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH.
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Abstract
Abstract During the early stages of the pandemic influenza A H1N1 2009 (pH1N1) outbreak in South Korea, the government recommended antiviral therapy with laboratory confirmation in specialized hospitals. Hence we had a unique opportunity to test all patients suspected to have pH1N1, including those who initially presented with a mild illness, such as those who were not in at-risk groups and who had an uncomplicated illness. We therefore evaluated the proportion and clinical features of pneumonia in patients with laboratory-confirmed pH1N1. Of the 3253 patients who visited Asan Medical Center, Seoul, South Korea, between 24 August and 19 October 2009 for a suspected pH1N1 infection (temperature ≥37.5°C and at least 1 of the following symptoms: sore throat, cough, rhinorrhoea and nasal congestion), 553 (17%) were positive for pH1N1 by real-time reverse-transcriptase polymerase chain reaction. Chest radiographs were performed in 96 (17%) of the 553 patients. Of the 553 patients, 30 (5%; 95% confidence interval (CI) 4–8%) had pneumonia, including 26 (86%) with viral pneumonia and 4 (14%) with bacterial pneumonia. So, the proportion of pneumonia in patients with laboratory-confirmed pH1N1 was at least 5%. Multivariate analysis indicated that dyspnoea (odds ratio (OR) 57.8, p < 0.001), wheezing (OR 19.3, p = 0.02), vomiting (OR 18.5, p < 0.001) and diarrhoea (OR 11.0, p = 0.001) were independently associated with pneumonia. Antiviral therapy at >48 h after the onset of symptoms (OR 2.1, p = 0.09) tended to be more common in patients with pneumonia than in those without pneumonia.
PMID: 20925450 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20925450