tetano
Editor, Senior Moderator
J Infect Dis. 2018 Dec 14. doi: 10.1093/infdis/jiy723. [Epub ahead of print]
[h=1]Prevention of influenza hospitalization among adults in the US, 2015-16: Results from the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).[/h] Ferdinands JM[SUP]1[/SUP], Gaglani M[SUP]2[/SUP], Martin ET[SUP]3[/SUP], Middleton D[SUP]4[/SUP], Monto AS[SUP]3[/SUP], Murthy K[SUP]2[/SUP], Silveira FP[SUP]4[/SUP], Talbot HK[SUP]5[/SUP], Zimmerman R[SUP]4[/SUP], Alyanak E[SUP]1[/SUP], Strickland C[SUP]1[/SUP], Spencer S[SUP]1[/SUP], Fry AM[SUP]1[/SUP]; HAIVEN Study Investigators.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Evidence establishing effectiveness of influenza vaccination for prevention of severe illness is limited. The US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) is a multi-year test-negative case-control study initiated in 2015-16 to estimate effectiveness of vaccine in preventing influenza hospitalization among adults.
[h=4]Methods:[/h] Adults aged ≥18 years admitted to eight US hospitals with acute respiratory illness and testing positive for influenza by PCR were cases; those testing negative were controls. VE was estimated with logistic regression adjusting for age, comorbidities and other confounding factors and stratified by frailty, two-year vaccination history, and clinical presentation.
[h=4]Results:[/h] We analyzed data from 236 cases and 1231 controls; mean age was 58 years. Over 90% of patients had ≥1 comorbidity elevating risk of influenza complications. Fifty percent of cases and 70% of controls were vaccinated. Vaccination was 51% (95%CI 29, 65) and 53% (95%CI 11, 76) effective in preventing hospitalization due to influenza A(H1N1)pdm09 and influenza B virus infection, respectively. Vaccine was protective for all age groups.
[h=4]Conclusions:[/h] During the 2015-16 US influenza A(H1N1)pdm09-predominant season, we found that vaccination halved the risk of influenza-association hospitalization among adults, most of whom were at increased risk of serious influenza complications due to comorbidity or age.
PMID: 30561689 DOI: 10.1093/infdis/jiy723
[h=1]Prevention of influenza hospitalization among adults in the US, 2015-16: Results from the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).[/h] Ferdinands JM[SUP]1[/SUP], Gaglani M[SUP]2[/SUP], Martin ET[SUP]3[/SUP], Middleton D[SUP]4[/SUP], Monto AS[SUP]3[/SUP], Murthy K[SUP]2[/SUP], Silveira FP[SUP]4[/SUP], Talbot HK[SUP]5[/SUP], Zimmerman R[SUP]4[/SUP], Alyanak E[SUP]1[/SUP], Strickland C[SUP]1[/SUP], Spencer S[SUP]1[/SUP], Fry AM[SUP]1[/SUP]; HAIVEN Study Investigators.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Evidence establishing effectiveness of influenza vaccination for prevention of severe illness is limited. The US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) is a multi-year test-negative case-control study initiated in 2015-16 to estimate effectiveness of vaccine in preventing influenza hospitalization among adults.
[h=4]Methods:[/h] Adults aged ≥18 years admitted to eight US hospitals with acute respiratory illness and testing positive for influenza by PCR were cases; those testing negative were controls. VE was estimated with logistic regression adjusting for age, comorbidities and other confounding factors and stratified by frailty, two-year vaccination history, and clinical presentation.
[h=4]Results:[/h] We analyzed data from 236 cases and 1231 controls; mean age was 58 years. Over 90% of patients had ≥1 comorbidity elevating risk of influenza complications. Fifty percent of cases and 70% of controls were vaccinated. Vaccination was 51% (95%CI 29, 65) and 53% (95%CI 11, 76) effective in preventing hospitalization due to influenza A(H1N1)pdm09 and influenza B virus infection, respectively. Vaccine was protective for all age groups.
[h=4]Conclusions:[/h] During the 2015-16 US influenza A(H1N1)pdm09-predominant season, we found that vaccination halved the risk of influenza-association hospitalization among adults, most of whom were at increased risk of serious influenza complications due to comorbidity or age.
PMID: 30561689 DOI: 10.1093/infdis/jiy723