Proc Natl Acad Sci U S A . Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection

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Proc Natl Acad Sci U S A


. 2024 Oct 15;121(42):e2413619121.
doi: 10.1073/pnas.2413619121. Epub 2024 Oct 9. Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection

Susanne Kessler[SUP] 1 2 [/SUP], Philipp Stegen[SUP] 1 2 [/SUP], Shijun Zhan[SUP] 3 [/SUP], Martin Schwemmle[SUP] 1 2 [/SUP], Peter Reuther[SUP] 1 2 [/SUP], Tony Schountz[SUP] 3 [/SUP], Kevin Ciminski[SUP] 1 2 3 [/SUP]



Affiliations

• PMID: 39382992
• DOI: 10.1073/pnas.2413619121

Abstract

Antibodies are an essential component of the antiviral response in many species, but to date, there is no compelling evidence that bats are capable of eliciting a robust humoral immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.

Keywords: Jamaican fruit bats; bat flu; bat influenza A virus H18N11; humoral immune response; neutralizing antibodies.

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