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Procalcitonin in patients with influenza A (H1N1) infection and acute respiratory failure

tetano

Editor, Senior Moderator
Einstein (Sao Paulo). 2011 Mar;9(1):52-5. doi: 10.1590/S1679-45082011AO1878.
[h=1]Procalcitonin in patients with influenza A (H1N1) infection and acute respiratory failure.[/h] [Article in English, Portuguese]
Duarte PA[SUP]1[/SUP], Bredt CS[SUP]2[/SUP], Bredt GL Jr[SUP]2[/SUP], Jorge AC[SUP]2[/SUP], Venazzi A[SUP]2[/SUP], Tondo LG[SUP]2[/SUP], Oliveira LS[SUP]2[/SUP], Jorge MM[SUP]2[/SUP], Marchiori R[SUP]2[/SUP], Giancursi TS[SUP]2[/SUP], Coradin M[SUP]2[/SUP], Alexandrino AG[SUP]2[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To verify serum procalcitonin levels of patients with acute respiratory failure secondary to influenza A (H1N1) upon their admission to the Intensive Care Unit and to compare these results to values found in patients with sepsis and trauma admitted to the same unit.
[h=4]METHODS:[/h] Analysis of records of patients infected with influenza A (H1N1) and respiratory failure admitted to the General Intensive Care Unit during in a period of 60 days. The values of serum procalcitonin and clinical and laboratory data were compared to those of all patients admitted with sepsis or trauma in the previous year.
[h=4]RESULTS:[/h] Among patients with influenza A (H1N1) (n = 16), the median serum procalcitonin level upon admission was 0.11 ng/mL, lower than in the sepsis group (p < 0.001) and slightly lower than in trauma patients. Although the mean values were low, serum procalcitonin was a strong predictor of hospital mortality in patients with influenza A (H1N1).
[h=4]CONCLUSION:[/h] Patients with influenza A (H1N1) with severe acute respiratory failure presented with low serum procalcitonin values upon admission, although their serum levels are predictors of hospital mortality. The kinetics study of this biomarker may be a useful tool in the management of this group of patients.


PMID: 26760553 [PubMed]
 
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