tetano
Editor, Senior Moderator
Curr Opin Virol. 2014 Apr 2;6C:34-39. doi: 10.1016/j.coviro.2014.02.008. [Epub ahead of print]
Production of live attenuated influenza vaccines against seasonal and potential pandemic influenza viruses.
Jin H1, Chen Z2.
Author information
Abstract
Vaccination remains the most effective means to prevent morbidity and mortality caused by influenza epidemics and pandemics. Live attenuated influenza vaccine (LAIV) has been proven to be effective in preventing influenza with broad cross reactivity to drifted strains. Owing to the sophisticated nature of the influenza vaccine production process, the time needed to develop high yield LAIV strains for vaccine production and product release remains a constant challenge. This review summarizes LAIV production process with highlights on the experiences gained during the past decade generating seasonal and pandemic LAIV seeds by reverse genetics strategy.
Copyright ? 2014. Published by Elsevier B.V.
PMID:
24705137
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24705137
Production of live attenuated influenza vaccines against seasonal and potential pandemic influenza viruses.
Jin H1, Chen Z2.
Author information
Abstract
Vaccination remains the most effective means to prevent morbidity and mortality caused by influenza epidemics and pandemics. Live attenuated influenza vaccine (LAIV) has been proven to be effective in preventing influenza with broad cross reactivity to drifted strains. Owing to the sophisticated nature of the influenza vaccine production process, the time needed to develop high yield LAIV strains for vaccine production and product release remains a constant challenge. This review summarizes LAIV production process with highlights on the experiences gained during the past decade generating seasonal and pandemic LAIV seeds by reverse genetics strategy.
Copyright ? 2014. Published by Elsevier B.V.
PMID:
24705137
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24705137