Mary Wilson
Well-known member
Aug 1, 2022
Sub-lineage of: BA.2.76
Earliest sequence: 2022-6-20, India, West Bengal, Howrah — EPI_ISL_13876813
Most recent sequence: 2022-7-13, India, West Bengal — EPI_ISL_14175293 (North 24 Parganas) and EPI_ISL_14175835 (Howrah)
Countries circulating: India—primarily West Bengal (42/45 sequences). One sequence each in Assam, Karnataka, and Tripura.
Number of Sequences: 49 in Usher Tree, 45 via GISAID search query “Spike_R346T, Spike_Y248N, Spike_R357K”
Substitutions on top of BA.2.76:
Spike: R357K
ORF1a: G1595S (NSP3_G777S)
ORF1b: V2073L (NSP15_V22L)
Nucleotide: G5048A, C7528T, C18555T, G19684T, G22632A, T29233A
USHER Tree
44 of the 45 sequences returned by the GISAID search query “Spike_R346T, Spike_Y248N, Spike_R357K” are in the subtree of BA.2.76 below. ...
Evidence
Before today (August 1), there were only four sequences on GISAID with R346T, Y248N, and R357K. Today 41 such sequences were uploaded, all with collection dates between June 20 and July 13. Though 42 of the 45 sequences are from West Bengal, the other three are widely distributed—Karnataka is on the opposite side of India, and Assam and Tripura are on the opposite side of Bangladesh from West Bengal. These are all in one country, but India is a virtual continent unto itself; an approximate European equivalent would be finding 42/45 sequences of a lineage in Spain and one each in Italy, Switzerland, and Poland. ...
https://github.com/cov-lineages/pango-designation/issues/899
Sub-lineage of: BA.2.76
Earliest sequence: 2022-6-20, India, West Bengal, Howrah — EPI_ISL_13876813
Most recent sequence: 2022-7-13, India, West Bengal — EPI_ISL_14175293 (North 24 Parganas) and EPI_ISL_14175835 (Howrah)
Countries circulating: India—primarily West Bengal (42/45 sequences). One sequence each in Assam, Karnataka, and Tripura.
Number of Sequences: 49 in Usher Tree, 45 via GISAID search query “Spike_R346T, Spike_Y248N, Spike_R357K”
Substitutions on top of BA.2.76:
Spike: R357K
ORF1a: G1595S (NSP3_G777S)
ORF1b: V2073L (NSP15_V22L)
Nucleotide: G5048A, C7528T, C18555T, G19684T, G22632A, T29233A
USHER Tree
44 of the 45 sequences returned by the GISAID search query “Spike_R346T, Spike_Y248N, Spike_R357K” are in the subtree of BA.2.76 below. ...
Evidence
Before today (August 1), there were only four sequences on GISAID with R346T, Y248N, and R357K. Today 41 such sequences were uploaded, all with collection dates between June 20 and July 13. Though 42 of the 45 sequences are from West Bengal, the other three are widely distributed—Karnataka is on the opposite side of India, and Assam and Tripura are on the opposite side of Bangladesh from West Bengal. These are all in one country, but India is a virtual continent unto itself; an approximate European equivalent would be finding 42/45 sequences of a lineage in Spain and one each in Italy, Switzerland, and Poland. ...
https://github.com/cov-lineages/pango-designation/issues/899