tetano
Editor, Senior Moderator
Viral Immunology
Protection of Ferrets from Infection by Swine-Origin 2009 A (H1N1) Influenza Virus by the Inactivated Vaccine
To cite this article:
Jin Soo Shin, Seon Do Hwang, Hyun Soo Kim, Sung Whan Cho, Sang Heui Seo. Viral Immunology. August 2010, 23(4): 395-402. doi:10.1089/vim.2010.0022.
Published in Volume: 23 Issue 4: August 16, 2010
Swine-origin pandemic 2009A (H1N1) influenza viruses are still infecting humans, and humans are currently being vaccinated with the inactivated vaccine of 2009A (H1N1) influenza virus. We wanted to determine the efficacy of 2009A (H1N1) inactivated vaccine in ferrets. Ferrets immunized with one dose (7.5μg) of 2009A (H1N1) inactivated vaccine were not protected from infections of either pandemic H1N1 or seasonal H1N1 influenza viruses, while ferrets immunized with two doses of 2009A (H1N1) inactivated vaccine were protected from infections of pandemic H1N1, but not seasonal H1N1 influenza viruses. IgG subtype of antibody was dominantly detected in tissues of immunized ferrets. Our study suggests that pandemic H1N1 vaccine may not elicit the antibody cross-reactive to the seasonal H1N1 influenza virus.
http://www.liebertonline.com/doi/abs/10.1089/vim.2010.0022
Protection of Ferrets from Infection by Swine-Origin 2009 A (H1N1) Influenza Virus by the Inactivated Vaccine
To cite this article:
Jin Soo Shin, Seon Do Hwang, Hyun Soo Kim, Sung Whan Cho, Sang Heui Seo. Viral Immunology. August 2010, 23(4): 395-402. doi:10.1089/vim.2010.0022.
Published in Volume: 23 Issue 4: August 16, 2010
Swine-origin pandemic 2009A (H1N1) influenza viruses are still infecting humans, and humans are currently being vaccinated with the inactivated vaccine of 2009A (H1N1) influenza virus. We wanted to determine the efficacy of 2009A (H1N1) inactivated vaccine in ferrets. Ferrets immunized with one dose (7.5μg) of 2009A (H1N1) inactivated vaccine were not protected from infections of either pandemic H1N1 or seasonal H1N1 influenza viruses, while ferrets immunized with two doses of 2009A (H1N1) inactivated vaccine were protected from infections of pandemic H1N1, but not seasonal H1N1 influenza viruses. IgG subtype of antibody was dominantly detected in tissues of immunized ferrets. Our study suggests that pandemic H1N1 vaccine may not elicit the antibody cross-reactive to the seasonal H1N1 influenza virus.
http://www.liebertonline.com/doi/abs/10.1089/vim.2010.0022