tetano
Editor, Senior Moderator
J Infect Dis. 2017 Dec 5. doi: 10.1093/infdis/jix629. [Epub ahead of print]
[h=1]Protective effect of maternal influenza vaccination on influenza in their infants: a prospective cohort study.[/h] Ohfuji S[SUP]1,[/SUP][SUP]2[/SUP], Deguchi M[SUP]3[/SUP], Tachibana D[SUP]4[/SUP], Koyama M[SUP]4[/SUP], Takagi T[SUP]5[/SUP], Yoshioka T[SUP]6[/SUP], Urae A[SUP]7[/SUP], Ito K[SUP]1,[/SUP][SUP]2[/SUP], Kase T[SUP]1,[/SUP][SUP]2[/SUP], Maeda A[SUP]1[/SUP], Kondo K[SUP]8[/SUP], Fukushima W[SUP]1,[/SUP][SUP]2[/SUP], Hirota Y[SUP]1,[/SUP][SUP]9,[/SUP][SUP]10[/SUP]; Osaka Pregnant Women Influenza Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Infants under 6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications.
[h=4]Methods:[/h] To examine the effectiveness of maternal influenza vaccination in preventing infants' influenza, we conducted a prospective cohort study among 3,441 infants born at the participating hospitals before the 2013/14 influenza season. At the time of recruitment, their mothers completed the questionnaire about influenza vaccination status for the 2013/14 season. The follow-up survey conducted after the end of the 2013/14 season to collect information regarding influenza diagnosis and hospitalization among infants.
[h=4]Results:[/h] During the 2013/14 influenza season, 71 infants (2%) were diagnosed with influenza and 13 infants (0.4%) were hospitalized with influenza. Maternal influenza vaccination (especially prenatal vaccination) showed a decreasing effect on infants' influenza. Vaccine effectiveness of prenatal vaccination was 61% (95% confidence interval: 16-81%), whereas that of postpartum vaccination was 53% (-28-83%). Although maternal influenza vaccination was also associated with decreasing influenza-related hospitalization of infants, vaccine effectiveness (73%) could not reach statistical significance due to the limited number of infants hospitalized due to influenza.
[h=4]Conclusions:[/h] The present findings indicated that pregnant women and postpartum women should receive influenza vaccination in order to protect their infants.
[h=4]KEYWORDS:[/h] Influenza; infants; maternal vaccination; prospective cohort study; vaccine effectiveness
PMID: 29216373 DOI: 10.1093/infdis/jix629
[h=1]Protective effect of maternal influenza vaccination on influenza in their infants: a prospective cohort study.[/h] Ohfuji S[SUP]1,[/SUP][SUP]2[/SUP], Deguchi M[SUP]3[/SUP], Tachibana D[SUP]4[/SUP], Koyama M[SUP]4[/SUP], Takagi T[SUP]5[/SUP], Yoshioka T[SUP]6[/SUP], Urae A[SUP]7[/SUP], Ito K[SUP]1,[/SUP][SUP]2[/SUP], Kase T[SUP]1,[/SUP][SUP]2[/SUP], Maeda A[SUP]1[/SUP], Kondo K[SUP]8[/SUP], Fukushima W[SUP]1,[/SUP][SUP]2[/SUP], Hirota Y[SUP]1,[/SUP][SUP]9,[/SUP][SUP]10[/SUP]; Osaka Pregnant Women Influenza Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Infants under 6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications.
[h=4]Methods:[/h] To examine the effectiveness of maternal influenza vaccination in preventing infants' influenza, we conducted a prospective cohort study among 3,441 infants born at the participating hospitals before the 2013/14 influenza season. At the time of recruitment, their mothers completed the questionnaire about influenza vaccination status for the 2013/14 season. The follow-up survey conducted after the end of the 2013/14 season to collect information regarding influenza diagnosis and hospitalization among infants.
[h=4]Results:[/h] During the 2013/14 influenza season, 71 infants (2%) were diagnosed with influenza and 13 infants (0.4%) were hospitalized with influenza. Maternal influenza vaccination (especially prenatal vaccination) showed a decreasing effect on infants' influenza. Vaccine effectiveness of prenatal vaccination was 61% (95% confidence interval: 16-81%), whereas that of postpartum vaccination was 53% (-28-83%). Although maternal influenza vaccination was also associated with decreasing influenza-related hospitalization of infants, vaccine effectiveness (73%) could not reach statistical significance due to the limited number of infants hospitalized due to influenza.
[h=4]Conclusions:[/h] The present findings indicated that pregnant women and postpartum women should receive influenza vaccination in order to protect their infants.
[h=4]KEYWORDS:[/h] Influenza; infants; maternal vaccination; prospective cohort study; vaccine effectiveness
PMID: 29216373 DOI: 10.1093/infdis/jix629