tetano
Editor, Senior Moderator
Psychiatry Investig
. 2021 Jun;18(6):523-529.
doi: 10.30773/pi.2021.0064. Epub 2021 Jun 24.
Association between Dementia and Clinical Outcome after COVID-19: A Nationwide Cohort Study with Propensity Score Matched Control in South Korea
Sheng-Min Wang[SUP] 1 [/SUP], See Hyun Park[SUP] 2 [/SUP], Nak-Young Kim[SUP] 3 [/SUP], Dong Woo Kang[SUP] 4 [/SUP], Hae-Ran Na[SUP] 1 [/SUP], Yoo Hyun Um[SUP] 5 [/SUP], Seunghoon Han[SUP] 2 [/SUP], Sung-Soo Park[SUP] 6 [/SUP], Hyun Kook Lim[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: Despite a high prevalence of dementia in older adults hospitalized with severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), or so called COVID-19, research investigating association between preexisting diagnoses of dementia and prognosis of COVID-19 is scarce. We aimed to investigate treatment outcome of patients with dementia after COVID-19.
Methods: We explored a nationwide cohort with a total of 2,800 subjects older than 50 years who were diagnosed with COVID-19 between January and April 2020. Among them, 223 patients had underlying dementia (dementia group). We matched 1:1 for each dementia- non-dementia group pair yielding 223 patients without dementia (no dementia group) using propensity score matching.
Results: Mortality rate after COVID-19 was higher in dementia group than in no dementia group (33.6% vs. 20.2%, p=0.002). Dementia group had higher proportion of patients requiring invasive ventilatory support than no dementia group (34.1% vs. 22.0%, p=0.006). Multivariable analysis showed that dementia group had a higher risk of mortality than no dementia group (odds ratio=3.05, p<0.001). We also found that patients in dementia group had a higher risk of needing invasive ventilatory support than those in no dementia group.
Conclusion: Our results suggest that system including strengthen quarantines are required for patients with dementia during the COVID- 19 pandemic.
Keywords: COVID-19; Dementia; Mortality.; SARS-CoV-2.
. 2021 Jun;18(6):523-529.
doi: 10.30773/pi.2021.0064. Epub 2021 Jun 24.
Association between Dementia and Clinical Outcome after COVID-19: A Nationwide Cohort Study with Propensity Score Matched Control in South Korea
Sheng-Min Wang[SUP] 1 [/SUP], See Hyun Park[SUP] 2 [/SUP], Nak-Young Kim[SUP] 3 [/SUP], Dong Woo Kang[SUP] 4 [/SUP], Hae-Ran Na[SUP] 1 [/SUP], Yoo Hyun Um[SUP] 5 [/SUP], Seunghoon Han[SUP] 2 [/SUP], Sung-Soo Park[SUP] 6 [/SUP], Hyun Kook Lim[SUP] 1 [/SUP]
Affiliations
- PMID: 34218641
- DOI: 10.30773/pi.2021.0064
Abstract
Objective: Despite a high prevalence of dementia in older adults hospitalized with severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), or so called COVID-19, research investigating association between preexisting diagnoses of dementia and prognosis of COVID-19 is scarce. We aimed to investigate treatment outcome of patients with dementia after COVID-19.
Methods: We explored a nationwide cohort with a total of 2,800 subjects older than 50 years who were diagnosed with COVID-19 between January and April 2020. Among them, 223 patients had underlying dementia (dementia group). We matched 1:1 for each dementia- non-dementia group pair yielding 223 patients without dementia (no dementia group) using propensity score matching.
Results: Mortality rate after COVID-19 was higher in dementia group than in no dementia group (33.6% vs. 20.2%, p=0.002). Dementia group had higher proportion of patients requiring invasive ventilatory support than no dementia group (34.1% vs. 22.0%, p=0.006). Multivariable analysis showed that dementia group had a higher risk of mortality than no dementia group (odds ratio=3.05, p<0.001). We also found that patients in dementia group had a higher risk of needing invasive ventilatory support than those in no dementia group.
Conclusion: Our results suggest that system including strengthen quarantines are required for patients with dementia during the COVID- 19 pandemic.
Keywords: COVID-19; Dementia; Mortality.; SARS-CoV-2.