tetano
Editor, Senior Moderator
J Infect. 2011 Apr 15. [Epub ahead of print]
Rate and influence of respiratory virus co-infection on pandemic (H1N1) influenza disease.
Esper FP, Spahlinger T, Zhou L.
Source
Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States; Department of Pediatrics, Division of Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, United States.
Abstract
OBJECTIVES:
Many patients with influenza have more than one viral agent with co-infection frequencies reported as high as 20%. The impact of respiratory virus copathogens on influenza disease is unclear. We sought to determine if respiratory virus co-infection with pandemic H1N1 altered clinical disease.
METHODS:
Respiratory samples from 229 and 267 patients identified with and without H1N1 influenza respectively were screened for the presence of 13 seasonal respiratory viruses by multiplex RT-PCR. Disease severity between coinfected and monoinfected H1N1 patients were quantified using a standardized clinical severity scale. Influenza viral load was calculated by quantitative RT-PCR.
RESULTS:
Thirty (13.1%) influenza samples screened positive for the presence of 31 viral copathogens. The most prominent copathogens included rhinovirus (61.3%), and coronaviruses (16.1%). Median clinical severity of both monoinfected and coinfected groups were 1. Patients coinfected with rhinovirus tended to have lower clinical severity (median 0), whereas non-rhinovirus co-infections had substantially higher clinical severity (median 2). No difference in H1N1 viral load was observed between coinfected and monoinfected groups.
CONCLUSIONS:
Respiratory viruses co-infect patients with influenza disease. Patients coinfected with rhinovirus had less severe disease while non-rhinovirus co-infections were associated with substantially higher severity without changes in influenza viral titer.
Copyright ? 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
PMID:
21546090
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21546090
Rate and influence of respiratory virus co-infection on pandemic (H1N1) influenza disease.
Esper FP, Spahlinger T, Zhou L.
Source
Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States; Department of Pediatrics, Division of Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, United States.
Abstract
OBJECTIVES:
Many patients with influenza have more than one viral agent with co-infection frequencies reported as high as 20%. The impact of respiratory virus copathogens on influenza disease is unclear. We sought to determine if respiratory virus co-infection with pandemic H1N1 altered clinical disease.
METHODS:
Respiratory samples from 229 and 267 patients identified with and without H1N1 influenza respectively were screened for the presence of 13 seasonal respiratory viruses by multiplex RT-PCR. Disease severity between coinfected and monoinfected H1N1 patients were quantified using a standardized clinical severity scale. Influenza viral load was calculated by quantitative RT-PCR.
RESULTS:
Thirty (13.1%) influenza samples screened positive for the presence of 31 viral copathogens. The most prominent copathogens included rhinovirus (61.3%), and coronaviruses (16.1%). Median clinical severity of both monoinfected and coinfected groups were 1. Patients coinfected with rhinovirus tended to have lower clinical severity (median 0), whereas non-rhinovirus co-infections had substantially higher clinical severity (median 2). No difference in H1N1 viral load was observed between coinfected and monoinfected groups.
CONCLUSIONS:
Respiratory viruses co-infect patients with influenza disease. Patients coinfected with rhinovirus had less severe disease while non-rhinovirus co-infections were associated with substantially higher severity without changes in influenza viral titer.
Copyright ? 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
PMID:
21546090
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21546090