JimO
Well-known member
I have found multiple papers indicating that avian influenza, including H7 viruses, transmit easily to mice without mutation. The four human isolates have E627K, while the avian isolates do not. This is not my area of expertise, but I still haven't seen any information related to testing of rodents for H7N9. Perhaps mice could be the connection between birds and humans?
Recent H5N1 avian Influenza A virus increases rapidly in virulence to mice after a single passage in mice
Masaji Mase, Nobuhiko Tanimura, Tadao Imada, Masatoshi Okamatsu, Kenji Tsukamoto and Shigeo Yamaguchi
Abstract
To evaluate the potential pathogenicity to mammals of the recent H5N1 avian Influenza A virus, viruses recovered from dead mice infected with A/chicken/Yamaguchi/7/2004 isolated in Japan were examined. All recovered viruses from the brains of dead mice infected with this strain (without any prior adaptation to mice) had substituted the amino acid at position 627 of the PB2 protein from glutamic acid to lysine. Their mouse lethality had increased by approximately 5?104 times over that of the original virus. Histopathological analysis reinforced the finding that these variants caused more rapid and severe damage to mice than the original virus. This revealed that it might be useful to characterize the recovered virus to assess its potential pathogenicity to mammals.
http://vir.sgmjournals.org/content/87/12/3655
Recent H5N1 avian Influenza A virus increases rapidly in virulence to mice after a single passage in mice
Masaji Mase, Nobuhiko Tanimura, Tadao Imada, Masatoshi Okamatsu, Kenji Tsukamoto and Shigeo Yamaguchi
Abstract
To evaluate the potential pathogenicity to mammals of the recent H5N1 avian Influenza A virus, viruses recovered from dead mice infected with A/chicken/Yamaguchi/7/2004 isolated in Japan were examined. All recovered viruses from the brains of dead mice infected with this strain (without any prior adaptation to mice) had substituted the amino acid at position 627 of the PB2 protein from glutamic acid to lysine. Their mouse lethality had increased by approximately 5?104 times over that of the original virus. Histopathological analysis reinforced the finding that these variants caused more rapid and severe damage to mice than the original virus. This revealed that it might be useful to characterize the recovered virus to assess its potential pathogenicity to mammals.
http://vir.sgmjournals.org/content/87/12/3655