tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2011 Aug 3. [Epub ahead of print]
Reduced Antibody Responses to the Pandemic (H1N1) 2009 Vaccine after Recent Seasonal Influenza Vaccination.
Choi YS, Baek YH, Kang W, Nam SJ, Lee J, You S, Chang DY, Youn JC, Choi YK, Shin EC.
Source
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Abstract
The vaccination program against the 2009 pandemic H1N1 influenza (2009 H1N1) provided a unique opportunity to determine if immune responses to the 2009 H1N1 vaccine were affected by a recent, prior vaccination against seasonal influenza. In the present study, we studied the immune responses to the 2009 H1N1 vaccine in subjects who either received the seasonal influenza vaccination within the prior three months or did not. Following 2009 H1N1 vaccination, subjects previously given a seasonal influenza vaccination exhibited significantly lower antibody responses, as determined by hemagglutination inhibition assay, than subjects who had not received the seasonal influenza vaccination. This result is compatible with the phenomenon of 'original antigenic sin', by which previous influenza vaccination hampers induction of immunity against a new variant. Our finding should be taken into account for future vaccination programs against pandemic influenza outbreaks.
PMID:
21813667
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21813667
Reduced Antibody Responses to the Pandemic (H1N1) 2009 Vaccine after Recent Seasonal Influenza Vaccination.
Choi YS, Baek YH, Kang W, Nam SJ, Lee J, You S, Chang DY, Youn JC, Choi YK, Shin EC.
Source
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Abstract
The vaccination program against the 2009 pandemic H1N1 influenza (2009 H1N1) provided a unique opportunity to determine if immune responses to the 2009 H1N1 vaccine were affected by a recent, prior vaccination against seasonal influenza. In the present study, we studied the immune responses to the 2009 H1N1 vaccine in subjects who either received the seasonal influenza vaccination within the prior three months or did not. Following 2009 H1N1 vaccination, subjects previously given a seasonal influenza vaccination exhibited significantly lower antibody responses, as determined by hemagglutination inhibition assay, than subjects who had not received the seasonal influenza vaccination. This result is compatible with the phenomenon of 'original antigenic sin', by which previous influenza vaccination hampers induction of immunity against a new variant. Our finding should be taken into account for future vaccination programs against pandemic influenza outbreaks.
PMID:
21813667
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21813667