tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2013 May 13. doi: 10.1111/irv.12121. [Epub ahead of print]
Regional variation in mortality impact of the 2009 A(H1N1) influenza pandemic in China.
Yu H, Feng L, Viboud CG, Shay DK, Jiang Y, Zhou H, Zhou M, Xu Z, Hu N, Yang W, Nie S.
Source
Department of Epidemiology and Statistics, Public Health School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Division of Infectious Diseases, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Abstract
BACKGROUND:
Laboratory-confirmed deaths grossly underestimate influenza mortality burden, so that reliable burden estimates are derived from indirect statistical studies, which are scarce in low- and middle-income settings.
OBJECTIVES:
Here, we used statistical excess mortality models to estimate the burden of seasonal and pandemic influenza in China.
METHODS:
We modeled data from a nationally representative population-based death registration system, combined with influenza virological surveillance data, to estimate influenza-associated excess mortality for the 2004-2005 through 2009-2010 seasons, by age and region.
RESULTS:
The A(H1N1) pandemic was associated with 11?4-12?1 excess respiratory and circulatory (R&C) deaths per 100 000 population in rural sites of northern and southern China during 2009-2010; these rates were 2?2-2?8 times higher than those of urban sites (P < 0?01). Influenza B accounted for a larger proportion of deaths than pandemic A(H1N1) in 2009-2010 in some regions. Nationally, we attribute 126 200 (95% CI, 61 000-248 400) excess R&C deaths (rate of 9?4/100 000) and 2 323 000 (1 166 000-4 533 000) years of life lost (YLL) to the first year of A(H1N1)pdm circulation.
CONCLUSIONS:
The A(H1N1) pandemic posed a mortality and YLL burden comparable to that of interpandemic influenza in China. Our high burden estimates in rural areas highlight the need to enhance epidemiological surveillance and healthcare services, in underdeveloped and remote areas.
? 2013 John Wiley & Sons Ltd.
PMID:
23668477
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23668477
Regional variation in mortality impact of the 2009 A(H1N1) influenza pandemic in China.
Yu H, Feng L, Viboud CG, Shay DK, Jiang Y, Zhou H, Zhou M, Xu Z, Hu N, Yang W, Nie S.
Source
Department of Epidemiology and Statistics, Public Health School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Division of Infectious Diseases, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Abstract
BACKGROUND:
Laboratory-confirmed deaths grossly underestimate influenza mortality burden, so that reliable burden estimates are derived from indirect statistical studies, which are scarce in low- and middle-income settings.
OBJECTIVES:
Here, we used statistical excess mortality models to estimate the burden of seasonal and pandemic influenza in China.
METHODS:
We modeled data from a nationally representative population-based death registration system, combined with influenza virological surveillance data, to estimate influenza-associated excess mortality for the 2004-2005 through 2009-2010 seasons, by age and region.
RESULTS:
The A(H1N1) pandemic was associated with 11?4-12?1 excess respiratory and circulatory (R&C) deaths per 100 000 population in rural sites of northern and southern China during 2009-2010; these rates were 2?2-2?8 times higher than those of urban sites (P < 0?01). Influenza B accounted for a larger proportion of deaths than pandemic A(H1N1) in 2009-2010 in some regions. Nationally, we attribute 126 200 (95% CI, 61 000-248 400) excess R&C deaths (rate of 9?4/100 000) and 2 323 000 (1 166 000-4 533 000) years of life lost (YLL) to the first year of A(H1N1)pdm circulation.
CONCLUSIONS:
The A(H1N1) pandemic posed a mortality and YLL burden comparable to that of interpandemic influenza in China. Our high burden estimates in rural areas highlight the need to enhance epidemiological surveillance and healthcare services, in underdeveloped and remote areas.
? 2013 John Wiley & Sons Ltd.
PMID:
23668477
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23668477