tetano
Editor, Senior Moderator
Med Intensiva. 2018 Feb 9. pii: S0210-5691(17)30363-7. doi: 10.1016/j.medin.2017.12.004. [Epub ahead of print]
[h=1]Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection.[/h] [Article in English, Spanish]
Rodr?guez A[SUP]1[/SUP], Reyes LF[SUP]2[/SUP], Monclou J[SUP]3[/SUP], Suberviola B[SUP]4[/SUP], Bod? M[SUP]3[/SUP], Sirgo G[SUP]3[/SUP], Sol?-Viol?n J[SUP]5[/SUP], Guardiola J[SUP]6[/SUP], Barahona D[SUP]7[/SUP], D?az E[SUP]8[/SUP], Mart?n-Loeches I[SUP]9[/SUP], Restrepo MI[SUP]2[/SUP]; on behalf GETGAG study group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection.
[h=4]OBJECTIVE:[/h] To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection.
[h=4]DESIGN:[/h] Secondary analysis of a prospective multicentre observational study.
[h=4]SETTING:[/h] 148 Spanish ICUs.
[h=4]PATIENTS:[/h] ICU patients admitted with influenza infection without bacterial co-infection. Clinical, laboratory and hemodynamic variables were recorded. AKI was classified as AKI I or II based on creatinine (Cr) concentrations (≥1.60-2.50mg/dL and Cr≥2.51-3.99mg/dL, respectively). Patients with chronic renal disease, receiving renal replacement treatment or with Cr>4mg/dL were excluded. Spearman's correlation, simple and multiple linear regression analysis were performed.
[h=4]INTERVENTIONS:[/h] None.
[h=4]RESULTS:[/h] Out of 663 patients included in the study, 52 (8.2%) and 10 (1.6%) developed AKI I and II, respectively. Patients with AKI were significantly older, had more comorbid conditions and were more severally ill. PCT concentrations were higher in patients with AKI (2.62 [0.60-10.0]ng/mL vs. 0.40 [0.13-1.20]ng/mL, p=0.002). Weak correlations between Cr/PCT (rho=0.18) and Urea (U)/PCT (rho=0.19) were identified. Simple linear regression showed poor interaction between Cr/U and PCT concentrations (Cr R[SUP]2[/SUP]=0.03 and U R[SUP]2[/SUP]=0.018). Similar results were observed during multiple linear regression analysis (Cr R[SUP]2[/SUP]=0.046 and U R[SUP]2[/SUP]=0.013).
[h=4]CONCLUSIONS:[/h] Although PCT concentrations were slightly higher in patients with AKI, high PCT concentrations are not explained by AKI and could be warning sign of a potential bacterial infection.
Copyright ? 2018 Elsevier Espa?a, S.L.U. y SEMICYUC. All rights reserved.
[h=4]KEYWORDS:[/h] Creatinina; Creatinine; Disfunci?n renal; Gripe; Influenza; Procalcitonin; Procalcitonina; Renal dysfunction; Urea
PMID: 29433841 DOI: 10.1016/j.medin.2017.12.004
[h=1]Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection.[/h] [Article in English, Spanish]
Rodr?guez A[SUP]1[/SUP], Reyes LF[SUP]2[/SUP], Monclou J[SUP]3[/SUP], Suberviola B[SUP]4[/SUP], Bod? M[SUP]3[/SUP], Sirgo G[SUP]3[/SUP], Sol?-Viol?n J[SUP]5[/SUP], Guardiola J[SUP]6[/SUP], Barahona D[SUP]7[/SUP], D?az E[SUP]8[/SUP], Mart?n-Loeches I[SUP]9[/SUP], Restrepo MI[SUP]2[/SUP]; on behalf GETGAG study group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection.
[h=4]OBJECTIVE:[/h] To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection.
[h=4]DESIGN:[/h] Secondary analysis of a prospective multicentre observational study.
[h=4]SETTING:[/h] 148 Spanish ICUs.
[h=4]PATIENTS:[/h] ICU patients admitted with influenza infection without bacterial co-infection. Clinical, laboratory and hemodynamic variables were recorded. AKI was classified as AKI I or II based on creatinine (Cr) concentrations (≥1.60-2.50mg/dL and Cr≥2.51-3.99mg/dL, respectively). Patients with chronic renal disease, receiving renal replacement treatment or with Cr>4mg/dL were excluded. Spearman's correlation, simple and multiple linear regression analysis were performed.
[h=4]INTERVENTIONS:[/h] None.
[h=4]RESULTS:[/h] Out of 663 patients included in the study, 52 (8.2%) and 10 (1.6%) developed AKI I and II, respectively. Patients with AKI were significantly older, had more comorbid conditions and were more severally ill. PCT concentrations were higher in patients with AKI (2.62 [0.60-10.0]ng/mL vs. 0.40 [0.13-1.20]ng/mL, p=0.002). Weak correlations between Cr/PCT (rho=0.18) and Urea (U)/PCT (rho=0.19) were identified. Simple linear regression showed poor interaction between Cr/U and PCT concentrations (Cr R[SUP]2[/SUP]=0.03 and U R[SUP]2[/SUP]=0.018). Similar results were observed during multiple linear regression analysis (Cr R[SUP]2[/SUP]=0.046 and U R[SUP]2[/SUP]=0.013).
[h=4]CONCLUSIONS:[/h] Although PCT concentrations were slightly higher in patients with AKI, high PCT concentrations are not explained by AKI and could be warning sign of a potential bacterial infection.
Copyright ? 2018 Elsevier Espa?a, S.L.U. y SEMICYUC. All rights reserved.
[h=4]KEYWORDS:[/h] Creatinina; Creatinine; Disfunci?n renal; Gripe; Influenza; Procalcitonin; Procalcitonina; Renal dysfunction; Urea
PMID: 29433841 DOI: 10.1016/j.medin.2017.12.004