tetano
Editor, Senior Moderator
Med Clin (Barc). 2019 Feb 6. pii: S0025-7753(18)30743-7. doi: 10.1016/j.medcli.2018.11.015. [Epub ahead of print]
[h=1]Relationship between seasonal influenza rates and hospitalization and mortality rates due to acute cardiovascular diseases in a Spanish region.[/h] [Article in English, Spanish]
L?pez-Fern?ndez L[SUP]1[/SUP], L?pez-Messa J[SUP]2[/SUP], Andr?s-de Llano J[SUP]3[/SUP], Garmendia-Leiza JR[SUP]3[/SUP], Garc?a-Cruces J[SUP]4[/SUP], Garc?a-Crespo J[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION AND OBJECTIVE:[/h] Influenza virus infection can contribute to cardiovascular morbidity and mortality. The purpose of this study is to confirm if the increase in seasonal influenza rates is associated with a growth in hospitalisation and mortality rates for acute cardiovascular diseases (ACVD).
[h=4]METHODS:[/h] Retrospective cohort study of hospital discharges due to ACVD (myocardial infarction, unstable angina, heart failure and ischemic stroke) in the Castilla y Le?n (Spain) hospital system between 2001 and 2015. Hospitalisation and hospital mortality rates due to ACVD, and influenza rates in Castilla y Le?n between 2001 and 2015 were studied. To calculate hospitalisation and mortality rates, the hospital discharges database was used; for influenza rates, the weekly reports of the Sentinel System for the surveillance of influenza in Spain (Carlos III Health Institute) were used. A statistical analysis of linear and multivariate logistic regressions was performed.
[h=4]RESULTS:[/h] 239,586 ACVD (myocardial infarction: 55,004; unstable angina: 15,406; heart failure: 11,1647; ischemic stroke: 57,529) were studied. Increasing rates of influenza were associated with increased mortality due to ACVD and all the diseases studied, except unstable angina. A linear correlation was observed between influenza rates and hospitalisation (r[SUP]2[/SUP]=0.03; p=0.02) and mortality (r[SUP]2[/SUP]=0.14; p<0.001) rates by ACVD. Virtually all influenza rates were associated, as independent variables, to an increase in mortality due to ACVD, being higher in rates>139/100,000 inhabitants (OR: 1.25; p<0.001).
[h=4]CONCLUSIONS:[/h] The rates of hospitalisation and in-hospital mortality due to ACVD in the period 2001-2015 increased in relation to infection rates due to the influenza virus.
Copyright ? 2018 Elsevier Espa?a, S.L.U. All rights reserved.
[h=4]KEYWORDS:[/h] Accidente cerebrovascular isqu?mico; Acute myocardial infarction; Angina inestable; Cardiovascular disease; Enfermedad cardiovascular; Gripe; Heart failure; Infarto agudo de miocardio; Influenza; Insuficiencia cardiaca; Ischemic stroke; Unstable angina
PMID: 30738617 DOI: 10.1016/j.medcli.2018.11.015
[h=1]Relationship between seasonal influenza rates and hospitalization and mortality rates due to acute cardiovascular diseases in a Spanish region.[/h] [Article in English, Spanish]
L?pez-Fern?ndez L[SUP]1[/SUP], L?pez-Messa J[SUP]2[/SUP], Andr?s-de Llano J[SUP]3[/SUP], Garmendia-Leiza JR[SUP]3[/SUP], Garc?a-Cruces J[SUP]4[/SUP], Garc?a-Crespo J[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION AND OBJECTIVE:[/h] Influenza virus infection can contribute to cardiovascular morbidity and mortality. The purpose of this study is to confirm if the increase in seasonal influenza rates is associated with a growth in hospitalisation and mortality rates for acute cardiovascular diseases (ACVD).
[h=4]METHODS:[/h] Retrospective cohort study of hospital discharges due to ACVD (myocardial infarction, unstable angina, heart failure and ischemic stroke) in the Castilla y Le?n (Spain) hospital system between 2001 and 2015. Hospitalisation and hospital mortality rates due to ACVD, and influenza rates in Castilla y Le?n between 2001 and 2015 were studied. To calculate hospitalisation and mortality rates, the hospital discharges database was used; for influenza rates, the weekly reports of the Sentinel System for the surveillance of influenza in Spain (Carlos III Health Institute) were used. A statistical analysis of linear and multivariate logistic regressions was performed.
[h=4]RESULTS:[/h] 239,586 ACVD (myocardial infarction: 55,004; unstable angina: 15,406; heart failure: 11,1647; ischemic stroke: 57,529) were studied. Increasing rates of influenza were associated with increased mortality due to ACVD and all the diseases studied, except unstable angina. A linear correlation was observed between influenza rates and hospitalisation (r[SUP]2[/SUP]=0.03; p=0.02) and mortality (r[SUP]2[/SUP]=0.14; p<0.001) rates by ACVD. Virtually all influenza rates were associated, as independent variables, to an increase in mortality due to ACVD, being higher in rates>139/100,000 inhabitants (OR: 1.25; p<0.001).
[h=4]CONCLUSIONS:[/h] The rates of hospitalisation and in-hospital mortality due to ACVD in the period 2001-2015 increased in relation to infection rates due to the influenza virus.
Copyright ? 2018 Elsevier Espa?a, S.L.U. All rights reserved.
[h=4]KEYWORDS:[/h] Accidente cerebrovascular isqu?mico; Acute myocardial infarction; Angina inestable; Cardiovascular disease; Enfermedad cardiovascular; Gripe; Heart failure; Infarto agudo de miocardio; Influenza; Insuficiencia cardiaca; Ischemic stroke; Unstable angina
PMID: 30738617 DOI: 10.1016/j.medcli.2018.11.015