tetano
Editor, Senior Moderator
Int Immunol. 2019 Jun 20. pii: dxz049. doi: 10.1093/intimm/dxz049. [Epub ahead of print]
[h=1]Requirement for memory B cell activation in protection from heterologous influenza virus reinfection.[/h] Leach S[SUP]1,[/SUP][SUP]2[/SUP], Shinnakasu R[SUP]2[/SUP], Adachi Y[SUP]3[/SUP], Momota M[SUP]4[/SUP], Makino-Okamura C[SUP]5[/SUP], Yamamoto T[SUP]6[/SUP], Ishii KJ[SUP]4[/SUP], Fukuyama H[SUP]5[/SUP], Takahashi Y[SUP]3[/SUP], Kurosaki T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] While two memory compartments, memory B cells and long-lived plasma cells, are thought to contribute to the successful establishment of memory recall responses, the unique roles of each cellular compartment are still unclear. Herein, by tracing influenza anti-hemagglutinin (HA)-specific antibodies in mice, we demonstrate that pre-existing antibodies secreted by long-lived plasma cells are essential for protection from re-infection with the same influenza virus, whereas protection from secondary infection with an antigenically distinct influenza virus requires memory B cell activation. These activated memory B cells were largely specific for the conserved HA stem region, and generated sufficient levels of antibodies for protection from heterologous reinfection. Given that the anti-stem plasmablasts derived from the memory B cells were higher affinity than those from na?ve B cells, our results suggest that maturation of anti-stem memory B cells during primary influenza infection and their subsequent activation are required for protection from re-infection by mutant viruses.
? The Japanese Society for Immunology. 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] antibody; cross-reactive; immunity; infection; virus
PMID: 31231764 DOI: 10.1093/intimm/dxz049
[h=1]Requirement for memory B cell activation in protection from heterologous influenza virus reinfection.[/h] Leach S[SUP]1,[/SUP][SUP]2[/SUP], Shinnakasu R[SUP]2[/SUP], Adachi Y[SUP]3[/SUP], Momota M[SUP]4[/SUP], Makino-Okamura C[SUP]5[/SUP], Yamamoto T[SUP]6[/SUP], Ishii KJ[SUP]4[/SUP], Fukuyama H[SUP]5[/SUP], Takahashi Y[SUP]3[/SUP], Kurosaki T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] While two memory compartments, memory B cells and long-lived plasma cells, are thought to contribute to the successful establishment of memory recall responses, the unique roles of each cellular compartment are still unclear. Herein, by tracing influenza anti-hemagglutinin (HA)-specific antibodies in mice, we demonstrate that pre-existing antibodies secreted by long-lived plasma cells are essential for protection from re-infection with the same influenza virus, whereas protection from secondary infection with an antigenically distinct influenza virus requires memory B cell activation. These activated memory B cells were largely specific for the conserved HA stem region, and generated sufficient levels of antibodies for protection from heterologous reinfection. Given that the anti-stem plasmablasts derived from the memory B cells were higher affinity than those from na?ve B cells, our results suggest that maturation of anti-stem memory B cells during primary influenza infection and their subsequent activation are required for protection from re-infection by mutant viruses.
? The Japanese Society for Immunology. 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] antibody; cross-reactive; immunity; infection; virus
PMID: 31231764 DOI: 10.1093/intimm/dxz049