tetano
Editor, Senior Moderator
Respir Med Res
. 2022 Mar 3;81:100900.
doi: 10.1016/j.resmer.2022.100900. Online ahead of print.
Characteristics and outcomes of COVID-19 patients with IPF: A multi-center retrospective study
Aykut Cilli[SUP] 1 [/SUP], Ismail Hanta[SUP] 2 [/SUP], Fatih Uzer[SUP] 3 [/SUP], Funda Coskun[SUP] 4 [/SUP], Can Sevinc[SUP] 5 [/SUP], Pelin Pınar Deniz[SUP] 2 [/SUP], Mehmet Parlak[SUP] 3 [/SUP], Ersoy Altunok[SUP] 2 [/SUP], Kemal Can Tertemiz[SUP] 5 [/SUP], Ahmet Ursavas[SUP] 4 [/SUP]
Affiliations
Abstract
Background: There are few data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19) infection in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study is to describe the characteristics and outcomes of IPF patients confirmed COVID-19 infection.
Methods: In this retrospective, multi-center, cohort study, patients from 4 hospital medical records with known IPF and a COVID-19 diagnosis were identified. Demographic and clinical outcome data were abstracted through a review of electronic medical records.
Results: Records for 46 patients with IPF and COVID-19 were abstracted. The mean age was 65±10 years. The most common symptom was dyspnea, followed by fever and cough. Ground-glass opacities (n = 35, 83.3%) and consolidations (n = 11, 26.1%) were the main imaging features of the disease in thorax computed tomography (CT). Twenty-four patients (52.1%) required hospitalization. Among the hospitalized patients, 16 (66.6%) were admitted to the intensive care unit (ICU), and 10 (41.6%) underwent invasive mechanical ventilation. Thirteen patients (28.2%) died of COVID-19 complications. Mortality rate was significantly associated with lower DLCO/VA, long term oxygen therapy and consolidation finding on CT of thorax (p<0.05). On multivariable analysis, neither factor was associated with hospitalization or mortality.
Conclusions: IPF patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, ICU requirement, and mortality rate. Measures to minimize the risk of COVID-19 infection remain key to protect IPF patients.
Keywords: Idiopathic pulmonary fibrosis; Interstitial lung disease; Outbreak; Pandemic; SARS-CoV-2.
. 2022 Mar 3;81:100900.
doi: 10.1016/j.resmer.2022.100900. Online ahead of print.
Characteristics and outcomes of COVID-19 patients with IPF: A multi-center retrospective study
Aykut Cilli[SUP] 1 [/SUP], Ismail Hanta[SUP] 2 [/SUP], Fatih Uzer[SUP] 3 [/SUP], Funda Coskun[SUP] 4 [/SUP], Can Sevinc[SUP] 5 [/SUP], Pelin Pınar Deniz[SUP] 2 [/SUP], Mehmet Parlak[SUP] 3 [/SUP], Ersoy Altunok[SUP] 2 [/SUP], Kemal Can Tertemiz[SUP] 5 [/SUP], Ahmet Ursavas[SUP] 4 [/SUP]
Affiliations
- PMID: 35338917
- PMCID: PMC8890788
- DOI: 10.1016/j.resmer.2022.100900
Abstract
Background: There are few data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19) infection in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study is to describe the characteristics and outcomes of IPF patients confirmed COVID-19 infection.
Methods: In this retrospective, multi-center, cohort study, patients from 4 hospital medical records with known IPF and a COVID-19 diagnosis were identified. Demographic and clinical outcome data were abstracted through a review of electronic medical records.
Results: Records for 46 patients with IPF and COVID-19 were abstracted. The mean age was 65±10 years. The most common symptom was dyspnea, followed by fever and cough. Ground-glass opacities (n = 35, 83.3%) and consolidations (n = 11, 26.1%) were the main imaging features of the disease in thorax computed tomography (CT). Twenty-four patients (52.1%) required hospitalization. Among the hospitalized patients, 16 (66.6%) were admitted to the intensive care unit (ICU), and 10 (41.6%) underwent invasive mechanical ventilation. Thirteen patients (28.2%) died of COVID-19 complications. Mortality rate was significantly associated with lower DLCO/VA, long term oxygen therapy and consolidation finding on CT of thorax (p<0.05). On multivariable analysis, neither factor was associated with hospitalization or mortality.
Conclusions: IPF patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, ICU requirement, and mortality rate. Measures to minimize the risk of COVID-19 infection remain key to protect IPF patients.
Keywords: Idiopathic pulmonary fibrosis; Interstitial lung disease; Outbreak; Pandemic; SARS-CoV-2.