tetano
Editor, Senior Moderator
Respir Res
. 2020 Jul 29;21(1):201.
doi: 10.1186/s12931-020-01465-2.
Association between cytokine profiles and lung injury in COVID-19 pneumonia
Li-Da Chen[SUP] 1 [/SUP], Zhen-Yu Zhang[SUP] 2 [/SUP], Xiao-Jie Wei[SUP] 3 [/SUP], Yu-Qing Cai[SUP] 4 [/SUP], Weng-Zhen Yao[SUP] 4 [/SUP], Ming-Hui Wang[SUP] 4 [/SUP], Qiu-Fen Huang[SUP] 4 [/SUP], Xiao-Bin Zhang[SUP] 5 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia.
Methods: This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio were used to assess lung injury.
Results: 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] (β = - 0.434, p = 0.003).
Conclusions: Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.
Keywords: Coronavirus disease 2019; Cytokine; Lung injury; Pneumonia; Severe acute respiratory syndrome coronavirus 2.
. 2020 Jul 29;21(1):201.
doi: 10.1186/s12931-020-01465-2.
Association between cytokine profiles and lung injury in COVID-19 pneumonia
Li-Da Chen[SUP] 1 [/SUP], Zhen-Yu Zhang[SUP] 2 [/SUP], Xiao-Jie Wei[SUP] 3 [/SUP], Yu-Qing Cai[SUP] 4 [/SUP], Weng-Zhen Yao[SUP] 4 [/SUP], Ming-Hui Wang[SUP] 4 [/SUP], Qiu-Fen Huang[SUP] 4 [/SUP], Xiao-Bin Zhang[SUP] 5 [/SUP]
Affiliations
- PMID: 32727465
- DOI: 10.1186/s12931-020-01465-2
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia.
Methods: This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio were used to assess lung injury.
Results: 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] (β = - 0.434, p = 0.003).
Conclusions: Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.
Keywords: Coronavirus disease 2019; Cytokine; Lung injury; Pneumonia; Severe acute respiratory syndrome coronavirus 2.