gsgs
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strain A ,
nucleotide area of fusion protein and glycoprotein
more contagious than flu - almost all children
had it by age 3
lower mutation rate than flu, seasonal outbreaks
not segmented, 11 proteins,enveloped
~15000 nucleotides
strains A,B alternating
oversummers in USA,Europe ?
Infected dendritic cells act as a reservoir for RSV over summer
http://thorax.bmj.com/content/65/Suppl_4/A14.1.abstract
MoDCs as a potential summer reservoir of RSV.
mutation rate is ~1.0 e-3 /position/year in the whole genome
(flu:2.5e-3) , maybe more (~2.5e-3) in the usually sequenced glycoprotein area
--------------------------------------
http://www.ncbi.nlm.nih.gov/pubmed/15994810
a 45-year period, including 196 Belgian strains obtained over 22 epidemic seasons (1982 to 2004).
HRSV-B evolutionary rate (1.95 x 10(-3) nucleotide substitutions/site/year)
is similar to that previously estimated for HRSV-A (1.83 x 10(-3) nucleotide substitutions/site/year).
(G protein genetic variability )
The most recent common ancestor of the currently circulating subgroup B strains was
estimated to date back to around the year 1949.
The divergence between the two major subgroups was calculated to have occurred
approximately 350 years ago.
-------------------------------------
USA 1994-2008
influenza hospitalizations : 635/M/year
RSV :553/M/year
http://www.ncbi.nlm.nih.gov/pubmed/22495079
-------------------------------------
nucleotide area of fusion protein and glycoprotein
more contagious than flu - almost all children
had it by age 3
lower mutation rate than flu, seasonal outbreaks
not segmented, 11 proteins,enveloped
~15000 nucleotides
strains A,B alternating
oversummers in USA,Europe ?
Infected dendritic cells act as a reservoir for RSV over summer
http://thorax.bmj.com/content/65/Suppl_4/A14.1.abstract
MoDCs as a potential summer reservoir of RSV.
mutation rate is ~1.0 e-3 /position/year in the whole genome
(flu:2.5e-3) , maybe more (~2.5e-3) in the usually sequenced glycoprotein area
--------------------------------------
http://www.ncbi.nlm.nih.gov/pubmed/15994810
a 45-year period, including 196 Belgian strains obtained over 22 epidemic seasons (1982 to 2004).
HRSV-B evolutionary rate (1.95 x 10(-3) nucleotide substitutions/site/year)
is similar to that previously estimated for HRSV-A (1.83 x 10(-3) nucleotide substitutions/site/year).
(G protein genetic variability )
The most recent common ancestor of the currently circulating subgroup B strains was
estimated to date back to around the year 1949.
The divergence between the two major subgroups was calculated to have occurred
approximately 350 years ago.
-------------------------------------
USA 1994-2008
influenza hospitalizations : 635/M/year
RSV :553/M/year
http://www.ncbi.nlm.nih.gov/pubmed/22495079
-------------------------------------
