tetano
Editor, Senior Moderator
J Infect. 2016 Sep 22. pii: S0163-4453(16)30242-0. doi: 10.1016/j.jinf.2016.09.003. [Epub ahead of print]
[h=1]Respiratory viruses and influenza-like illness: epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample.[/h] Taylor S[SUP]1[/SUP], Lopez P[SUP]2[/SUP], Weckx L[SUP]3[/SUP], Borja-Tabora C[SUP]4[/SUP], Ulloa-Gutierrez R[SUP]5[/SUP], Lazcano-Ponce E[SUP]6[/SUP], Kerdpanich A[SUP]7[/SUP], Weber MA[SUP]8[/SUP], de Los Santos AM[SUP]9[/SUP], Tinoco JC[SUP]10[/SUP], Safadi MA[SUP]11[/SUP], Seng LF[SUP]12[/SUP], Mezerville MH[SUP]5[/SUP], Faingezicht I[SUP]5[/SUP], Cruz-Valdez A[SUP]6[/SUP], Feng Y[SUP]13[/SUP], Li P[SUP]14[/SUP], Durviaux S[SUP]13[/SUP], Haars G[SUP]13[/SUP], Roy-Ghanta S[SUP]14[/SUP], Vaughn DW[SUP]14[/SUP], Nolan T[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Better population data on respiratory viruses in children in tropical and southern hemisphere countries is needed.
[h=4]METHODS:[/h] The epidemiology of respiratory viruses among healthy children (6 months to <10 years) with influenza-like illness (ILI) was determined in a population sample derived from an influenza vaccine trial (NCT01051661) in 17 centers in eight countries (Australia, South East Asia and Latin America). Active surveillance for ILI was conducted for approximately 1 year (between February 2010 and August 2011), with PCR analysis of nasal and throat swabs.
[h=4]RESULTS:[/h] 6266 children were included, of whom 2421 experienced 3717 ILI episodes. Rhinovirus/enterovirus had the highest prevalence (41.5%), followed by influenza (15.8%), adenovirus (9.8%), parainfluenza and respiratory syncytial virus (RSV) (both 9.7%), coronavirus (5.6%), human metapneumovirus (5.5%) and human bocavirus (HBov) (2.0%). Corresponding incidence per 100 person-years was 29.78, 11.34, 7.03, 6.96, 6.94, 4.00, 3.98 and 1.41. Except for influenza, respiratory virus prevalence declined with age. The incidence of medically-attended ILI associated with viral infection ranged from 1.03 (HBov) to 23.69 (rhinovirus/enterovirus). The percentage of children missing school or daycare ranged from 21.4% (HBov) to 52.1% (influenza).
[h=4]CONCLUSIONS:[/h] Active surveillance of healthy children provided evidence of respiratory illness burden associated with several viruses, with a substantial burden in older children.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] active surveillance; healthy children; incidence; influenza-like illness; prevalence; respiratory viruses
PMID: 27667752 DOI: 10.1016/j.jinf.2016.09.003
[PubMed - as supplied by publisher]
[h=1]Respiratory viruses and influenza-like illness: epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample.[/h] Taylor S[SUP]1[/SUP], Lopez P[SUP]2[/SUP], Weckx L[SUP]3[/SUP], Borja-Tabora C[SUP]4[/SUP], Ulloa-Gutierrez R[SUP]5[/SUP], Lazcano-Ponce E[SUP]6[/SUP], Kerdpanich A[SUP]7[/SUP], Weber MA[SUP]8[/SUP], de Los Santos AM[SUP]9[/SUP], Tinoco JC[SUP]10[/SUP], Safadi MA[SUP]11[/SUP], Seng LF[SUP]12[/SUP], Mezerville MH[SUP]5[/SUP], Faingezicht I[SUP]5[/SUP], Cruz-Valdez A[SUP]6[/SUP], Feng Y[SUP]13[/SUP], Li P[SUP]14[/SUP], Durviaux S[SUP]13[/SUP], Haars G[SUP]13[/SUP], Roy-Ghanta S[SUP]14[/SUP], Vaughn DW[SUP]14[/SUP], Nolan T[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Better population data on respiratory viruses in children in tropical and southern hemisphere countries is needed.
[h=4]METHODS:[/h] The epidemiology of respiratory viruses among healthy children (6 months to <10 years) with influenza-like illness (ILI) was determined in a population sample derived from an influenza vaccine trial (NCT01051661) in 17 centers in eight countries (Australia, South East Asia and Latin America). Active surveillance for ILI was conducted for approximately 1 year (between February 2010 and August 2011), with PCR analysis of nasal and throat swabs.
[h=4]RESULTS:[/h] 6266 children were included, of whom 2421 experienced 3717 ILI episodes. Rhinovirus/enterovirus had the highest prevalence (41.5%), followed by influenza (15.8%), adenovirus (9.8%), parainfluenza and respiratory syncytial virus (RSV) (both 9.7%), coronavirus (5.6%), human metapneumovirus (5.5%) and human bocavirus (HBov) (2.0%). Corresponding incidence per 100 person-years was 29.78, 11.34, 7.03, 6.96, 6.94, 4.00, 3.98 and 1.41. Except for influenza, respiratory virus prevalence declined with age. The incidence of medically-attended ILI associated with viral infection ranged from 1.03 (HBov) to 23.69 (rhinovirus/enterovirus). The percentage of children missing school or daycare ranged from 21.4% (HBov) to 52.1% (influenza).
[h=4]CONCLUSIONS:[/h] Active surveillance of healthy children provided evidence of respiratory illness burden associated with several viruses, with a substantial burden in older children.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] active surveillance; healthy children; incidence; influenza-like illness; prevalence; respiratory viruses
PMID: 27667752 DOI: 10.1016/j.jinf.2016.09.003
[PubMed - as supplied by publisher]