tetano
Editor, Senior Moderator
Respirol Case Rep
. 2025 Aug 21;13(8):e70274.
doi: 10.1002/rcr2.70274. eCollection 2025 Aug. COVID-19 Vaccine-Induced Severe Pneumonitis
Tatsuro Suzuki[SUP] 1 2 [/SUP], Hiromi Furuta[SUP] 1 [/SUP], Misa Naganawa[SUP] 1 [/SUP], Keiko Hayashi[SUP] 1 [/SUP], Hiroko Kiyotoshi[SUP] 1 [/SUP], Chiharu Ohta[SUP] 1 [/SUP], Shigemitsu Ninomiya[SUP] 1 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) has resulted in global morbidity, mortality, and societal disruption. COVID-19 mRNA vaccination was mandatory in many countries for a period; however, severe adverse events have been observed in some individuals who received the vaccine. We report a case of COVID-19 mRNA vaccine-induced pneumonitis in a male patient whose cytokine levels were analysed prior to admission. His serum IgE level was high (347 U/mL), and several cytokines were elevated: TNFα was 1.2 pg/mL, IL-6 was 156 pg/mL, and IL-8 was 75.0 pg/mL. The patient developed severe respiratory failure requiring ventilatory support but recovered after steroid pulse therapy.
Keywords: COVID‐19; cytokine; interstitial pneumonia; vaccine.
. 2025 Aug 21;13(8):e70274.
doi: 10.1002/rcr2.70274. eCollection 2025 Aug. COVID-19 Vaccine-Induced Severe Pneumonitis
Tatsuro Suzuki[SUP] 1 2 [/SUP], Hiromi Furuta[SUP] 1 [/SUP], Misa Naganawa[SUP] 1 [/SUP], Keiko Hayashi[SUP] 1 [/SUP], Hiroko Kiyotoshi[SUP] 1 [/SUP], Chiharu Ohta[SUP] 1 [/SUP], Shigemitsu Ninomiya[SUP] 1 [/SUP]
Affiliations
- PMID: 40860748
- PMCID: PMC12371123
- DOI: 10.1002/rcr2.70274
Coronavirus disease 2019 (COVID-19) has resulted in global morbidity, mortality, and societal disruption. COVID-19 mRNA vaccination was mandatory in many countries for a period; however, severe adverse events have been observed in some individuals who received the vaccine. We report a case of COVID-19 mRNA vaccine-induced pneumonitis in a male patient whose cytokine levels were analysed prior to admission. His serum IgE level was high (347 U/mL), and several cytokines were elevated: TNFα was 1.2 pg/mL, IL-6 was 156 pg/mL, and IL-8 was 75.0 pg/mL. The patient developed severe respiratory failure requiring ventilatory support but recovered after steroid pulse therapy.
Keywords: COVID‐19; cytokine; interstitial pneumonia; vaccine.