tetano
Editor, Senior Moderator
Trends Microbiol. 2014 Oct 22. pii: S0966-842X(14)00198-X. doi: 10.1016/j.tim.2014.09.007. [Epub ahead of print]
Response of host inflammasomes to viral infection.
Chen IY1, Ichinohe T2.
Author information
Abstract
Inflammasomes are multiprotein complexes that induce downstream immune responses to specific pathogens, environmental stimuli, and host cell damage. Components of specific viruses activate different inflammasomes; for example, the influenza A virus M2 protein and encephalomyocarditis virus (EMCV) 2B protein activate the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome, whereas viral double-stranded RNA (dsRNA) activates the retinoic acid inducible gene-I (RIG-I) inflammasome. Once activated in response to viral infection, inflammasomes induce the activation of caspases and the release of mature forms of interleukin-1β (IL-1β) and IL-18. Here we review the association between viral infection and inflammasome activation. Identifying the mechanisms underlying virus-induced inflammasome activation is important if we are to develop novel therapeutic strategies to target viruses.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
IL-1β; NLRP3; caspase; inflammasome; pattern recognition receptors; viroporin
PMID:
25456015
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25456015
Response of host inflammasomes to viral infection.
Chen IY1, Ichinohe T2.
Author information
Abstract
Inflammasomes are multiprotein complexes that induce downstream immune responses to specific pathogens, environmental stimuli, and host cell damage. Components of specific viruses activate different inflammasomes; for example, the influenza A virus M2 protein and encephalomyocarditis virus (EMCV) 2B protein activate the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome, whereas viral double-stranded RNA (dsRNA) activates the retinoic acid inducible gene-I (RIG-I) inflammasome. Once activated in response to viral infection, inflammasomes induce the activation of caspases and the release of mature forms of interleukin-1β (IL-1β) and IL-18. Here we review the association between viral infection and inflammasome activation. Identifying the mechanisms underlying virus-induced inflammasome activation is important if we are to develop novel therapeutic strategies to target viruses.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
IL-1β; NLRP3; caspase; inflammasome; pattern recognition receptors; viroporin
PMID:
25456015
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25456015