tetano
Editor, Senior Moderator
Clin Exp Immunol. 2015 Oct 1. doi: 10.1111/cei.12718. [Epub ahead of print]
[h=1]Retinol binding protein and vitamin D associations with serum antibody isotypes, serum influenza virus-specific neutralizing activities, and airway cytokine profiles.[/h] Jones BG[SUP]1[/SUP], Oshansky CM[SUP]2[/SUP], Bajracharya R[SUP]2[/SUP], Tang L[SUP]3[/SUP], Sun Y[SUP]3[/SUP], Wong SS[SUP]1[/SUP], Webby R[SUP]1,[/SUP][SUP]4[/SUP], Thomas PG[SUP]2,[/SUP][SUP]4[/SUP], Hurwitz JL[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vitamin A supports the induction of IgA responses at mucosal surfaces in mice, but much less is known about the influence of vitamins on antibody isotype expression in humans. To address this knowledge gap, we examined forty six-residual blood samples from adults and children in the United States, some of whom were experiencing influenza virus infections of the respiratory tract. Assays were performed for retinol binding protein (RBP, a surrogate for vitamin A), vitamin D (a related vitamin), and antibody isotypes. Results showed that all but two tested samples exhibited RBP and/or vitamin D insufficiencies or deficiencies. Vitamin D correlated with blood IgM and IgG3, while RBP correlated with IgG4 and IgA. RBP also correlated positively with age and with influenza virus-specific antibody neutralization titers. Individuals with low blood RBP levels exhibited the highest frequencies of overexpressed cytokines and growth factors in nasal wash samples, an indication of inflamed mucosal tissues. While cause-effect relationships were not discerned, results support a hypothesis that vitamins directly influence B cell isotype expression in humans, and by doing so may help protect mucosal surfaces from respiratory viral disease. This article is protected by copyright. All rights reserved.
? 2015 British Society for Immunology.
PMID: 26425827 [PubMed - as supplied by publisher]
[h=1]Retinol binding protein and vitamin D associations with serum antibody isotypes, serum influenza virus-specific neutralizing activities, and airway cytokine profiles.[/h] Jones BG[SUP]1[/SUP], Oshansky CM[SUP]2[/SUP], Bajracharya R[SUP]2[/SUP], Tang L[SUP]3[/SUP], Sun Y[SUP]3[/SUP], Wong SS[SUP]1[/SUP], Webby R[SUP]1,[/SUP][SUP]4[/SUP], Thomas PG[SUP]2,[/SUP][SUP]4[/SUP], Hurwitz JL[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vitamin A supports the induction of IgA responses at mucosal surfaces in mice, but much less is known about the influence of vitamins on antibody isotype expression in humans. To address this knowledge gap, we examined forty six-residual blood samples from adults and children in the United States, some of whom were experiencing influenza virus infections of the respiratory tract. Assays were performed for retinol binding protein (RBP, a surrogate for vitamin A), vitamin D (a related vitamin), and antibody isotypes. Results showed that all but two tested samples exhibited RBP and/or vitamin D insufficiencies or deficiencies. Vitamin D correlated with blood IgM and IgG3, while RBP correlated with IgG4 and IgA. RBP also correlated positively with age and with influenza virus-specific antibody neutralization titers. Individuals with low blood RBP levels exhibited the highest frequencies of overexpressed cytokines and growth factors in nasal wash samples, an indication of inflamed mucosal tissues. While cause-effect relationships were not discerned, results support a hypothesis that vitamins directly influence B cell isotype expression in humans, and by doing so may help protect mucosal surfaces from respiratory viral disease. This article is protected by copyright. All rights reserved.
? 2015 British Society for Immunology.
PMID: 26425827 [PubMed - as supplied by publisher]