tetano
Editor, Senior Moderator
Immunol Cell Biol. 2011 Aug 16. doi: 10.1038/icb.2011.70. [Epub ahead of print]
Return of inactivated whole-virus vaccine for superior efficacy.
Furuya Y.
Source
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Abstract
The swine, influenza, H1N1 outbreak in 2009 highlighted the inadequacy of the currently used antibody-based vaccine strategies as a preventive measure for combating influenza pandemics. The ultimate goal for successful control of newly arising influenza outbreaks is to design a single-shot vaccine that will provide long-lasting immunity against all strains of influenza A virus. A large amount of data from animal studies has indicated that the cross-reactive cytotoxic T (Tc) cell response against conserved influenza virus epitopes may be the key immune response needed for a universal influenza vaccine. However, decades of research have shown that the development of safe T-cell-based vaccines for influenza is not an easy task. Here, I discuss the overlooked but potentially highly advantageous inactivation method, namely, γ-ray irradiation, as a mean to reach the Holy Grail of influenza vaccinology.Immunology and Cell Biology advance online publication, 16 August 2011; doi:10.1038/icb.2011.70.
PMID:
21844883
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21844883
Return of inactivated whole-virus vaccine for superior efficacy.
Furuya Y.
Source
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Abstract
The swine, influenza, H1N1 outbreak in 2009 highlighted the inadequacy of the currently used antibody-based vaccine strategies as a preventive measure for combating influenza pandemics. The ultimate goal for successful control of newly arising influenza outbreaks is to design a single-shot vaccine that will provide long-lasting immunity against all strains of influenza A virus. A large amount of data from animal studies has indicated that the cross-reactive cytotoxic T (Tc) cell response against conserved influenza virus epitopes may be the key immune response needed for a universal influenza vaccine. However, decades of research have shown that the development of safe T-cell-based vaccines for influenza is not an easy task. Here, I discuss the overlooked but potentially highly advantageous inactivation method, namely, γ-ray irradiation, as a mean to reach the Holy Grail of influenza vaccinology.Immunology and Cell Biology advance online publication, 16 August 2011; doi:10.1038/icb.2011.70.
PMID:
21844883
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21844883