tetano
Editor, Senior Moderator
Rev Bras Ginecol Obstet
. 2021 Dec;43(12):949-960.
doi: 10.1055/s-0041-1733913. Epub 2021 Dec 21.
Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review
Sarah Nilkece Mesquita Araújo Nogueira Bastos[SUP] 1 [/SUP], Bárbara Louise Freire Barbosa[SUP] 1 [/SUP], Larisse Giselle Barbosa Cruz[SUP] 1 [/SUP], Rayza Pereira de Souza[SUP] 2 [/SUP], Simone Santos E Silva Melo[SUP] 1 [/SUP], Caroline Camargo Bandeira da Silveira Luz[SUP] 1 [/SUP]
Affiliations
Abstract
in English, Portuguese
Objective: To analyze the clinical and obstetric aspects of pregnant women with COVID-19.
Methods: A systematic literature review in the MEDLINE/PubMed, LILACS, SCIELO, and CNKI databases was performed from March to May 2020, with the descriptors: Pregnancy; 2019-nCov; Coronavirus; SARS-Cov-2, Covid-19. Of those chosen were original titles, without language and period restriction and that addressed pregnant women with a clinical and/or laboratory diagnosis of COVID-19. Revisions, editorials, and duplicate titles were excluded. The Newcastle-Ottawa (NOS) and Murad et al. scales were used to assess the quality of the studies.
Results: We included 34 articles with 412 pregnant women infected with severe acute respiratory syndrome (SARS-Cov-2), with an average age of 27.5 years of age and 36.0 gestational weeks. The most common symptom was fever (205 [49.7%]), and 89 (21.6%) pregnant women progressed to severe viral pneumonia. Laboratory tests showed an increase in C-reactive protein (154 [37.8%]), and radiological tests showed pneumonia with peripheral ground-glass pattern (172 [51.4%]). Emergency cesarean delivery was indicated for most pregnant women, and the most common gestational complication was premature rupture of ovarian membranes (14 [3.4%;]). We detected 2 (0.5%) neonatal deaths, 2 (0.5%) stillbirths, and 1 (0.2%) maternal death.
Conclusion: Pregnant women with COVID-19 presented a clinical picture similar to that of non-infected pregnant women, with few obstetric or neonatal repercussions. There was a greater indication of cesarean deliveries before the disease aggravated, and there was no evidence of vertical transmission of the infection.
. 2021 Dec;43(12):949-960.
doi: 10.1055/s-0041-1733913. Epub 2021 Dec 21.
Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review
Sarah Nilkece Mesquita Araújo Nogueira Bastos[SUP] 1 [/SUP], Bárbara Louise Freire Barbosa[SUP] 1 [/SUP], Larisse Giselle Barbosa Cruz[SUP] 1 [/SUP], Rayza Pereira de Souza[SUP] 2 [/SUP], Simone Santos E Silva Melo[SUP] 1 [/SUP], Caroline Camargo Bandeira da Silveira Luz[SUP] 1 [/SUP]
Affiliations
- PMID: 34933389
- DOI: 10.1055/s-0041-1733913
Abstract
in English, Portuguese
Objective: To analyze the clinical and obstetric aspects of pregnant women with COVID-19.
Methods: A systematic literature review in the MEDLINE/PubMed, LILACS, SCIELO, and CNKI databases was performed from March to May 2020, with the descriptors: Pregnancy; 2019-nCov; Coronavirus; SARS-Cov-2, Covid-19. Of those chosen were original titles, without language and period restriction and that addressed pregnant women with a clinical and/or laboratory diagnosis of COVID-19. Revisions, editorials, and duplicate titles were excluded. The Newcastle-Ottawa (NOS) and Murad et al. scales were used to assess the quality of the studies.
Results: We included 34 articles with 412 pregnant women infected with severe acute respiratory syndrome (SARS-Cov-2), with an average age of 27.5 years of age and 36.0 gestational weeks. The most common symptom was fever (205 [49.7%]), and 89 (21.6%) pregnant women progressed to severe viral pneumonia. Laboratory tests showed an increase in C-reactive protein (154 [37.8%]), and radiological tests showed pneumonia with peripheral ground-glass pattern (172 [51.4%]). Emergency cesarean delivery was indicated for most pregnant women, and the most common gestational complication was premature rupture of ovarian membranes (14 [3.4%;]). We detected 2 (0.5%) neonatal deaths, 2 (0.5%) stillbirths, and 1 (0.2%) maternal death.
Conclusion: Pregnant women with COVID-19 presented a clinical picture similar to that of non-infected pregnant women, with few obstetric or neonatal repercussions. There was a greater indication of cesarean deliveries before the disease aggravated, and there was no evidence of vertical transmission of the infection.