tetano
Editor, Senior Moderator
Rev Inst Med Trop Sao Paulo
. 2021 Jul 5;63:e58.
doi: 10.1590/S1678-9946202163058. eCollection 2021.
Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2
Mariana Soares da Silva[SUP] 1 [/SUP], Meriane Demoliner[SUP] 1 [/SUP], Alana Witt Hansen[SUP] 1 [/SUP], Juliana Schons Gularte[SUP] 1 [/SUP], Flávio Silveira[SUP] 1 [/SUP], Fágner Henrique Heldt[SUP] 1 [/SUP], Micheli Filippi[SUP] 1 [/SUP], Vyctoria Malayhka de Abreu Góes Pereira[SUP] 1 [/SUP], Francini Pereira da Silva[SUP] 1 [/SUP], Larissa Mallmann[SUP] 1 [/SUP], Pietra Fink[SUP] 1 [/SUP], Luana Letícia da Silva[SUP] 2 [/SUP], Matheus Nunes Weber[SUP] 1 [/SUP], Paula Rodrigues de Almeida[SUP] 1 [/SUP], Juliane Deise Fleck[SUP] 1 [/SUP], Fernando Rosado Spilki[SUP] 1 [/SUP]
Affiliations
Abstract
Multiple variants of the Severe Acute Respiratory Syndrome coronavirus 2 virus (SARS-CoV-2) have been constantly reported across the world. The B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated the P.1 variant of concern (VOC), recently named as the Gamma variant by the newly WHO nomenclature proposal, and P.2 as a variant of interest (VOI). Here we describe an early case of P.1 primary infection in Southern Brazil in late November 2020, soon after the emergence of the variant in Manaus, Northern Brazil. The same male patient was reinfected by another B.1.1.28 variant, namely P.2, in March, 2021. The genomic analysis confirmed genetically significant differences between the two viruses recovered in both infections, the P.1 lineage in the first episode and P.2 in the reinfection. Due the very early detection of P.1, we have also investigated the circulation of P.1 in the same region by differential RT-qPCR, showing that this was an isolated case of P.1 at the time of detection, and this variant has disseminated and became prominent from late January to the end of March, 2021. SARS-CoV-2 recent reports of reinfection have raised critical questions on whether and how well a first infection protects against reinfection.
. 2021 Jul 5;63:e58.
doi: 10.1590/S1678-9946202163058. eCollection 2021.
Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2
Mariana Soares da Silva[SUP] 1 [/SUP], Meriane Demoliner[SUP] 1 [/SUP], Alana Witt Hansen[SUP] 1 [/SUP], Juliana Schons Gularte[SUP] 1 [/SUP], Flávio Silveira[SUP] 1 [/SUP], Fágner Henrique Heldt[SUP] 1 [/SUP], Micheli Filippi[SUP] 1 [/SUP], Vyctoria Malayhka de Abreu Góes Pereira[SUP] 1 [/SUP], Francini Pereira da Silva[SUP] 1 [/SUP], Larissa Mallmann[SUP] 1 [/SUP], Pietra Fink[SUP] 1 [/SUP], Luana Letícia da Silva[SUP] 2 [/SUP], Matheus Nunes Weber[SUP] 1 [/SUP], Paula Rodrigues de Almeida[SUP] 1 [/SUP], Juliane Deise Fleck[SUP] 1 [/SUP], Fernando Rosado Spilki[SUP] 1 [/SUP]
Affiliations
- PMID: 34231823
- DOI: 10.1590/S1678-9946202163058
Abstract
Multiple variants of the Severe Acute Respiratory Syndrome coronavirus 2 virus (SARS-CoV-2) have been constantly reported across the world. The B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated the P.1 variant of concern (VOC), recently named as the Gamma variant by the newly WHO nomenclature proposal, and P.2 as a variant of interest (VOI). Here we describe an early case of P.1 primary infection in Southern Brazil in late November 2020, soon after the emergence of the variant in Manaus, Northern Brazil. The same male patient was reinfected by another B.1.1.28 variant, namely P.2, in March, 2021. The genomic analysis confirmed genetically significant differences between the two viruses recovered in both infections, the P.1 lineage in the first episode and P.2 in the reinfection. Due the very early detection of P.1, we have also investigated the circulation of P.1 in the same region by differential RT-qPCR, showing that this was an isolated case of P.1 at the time of detection, and this variant has disseminated and became prominent from late January to the end of March, 2021. SARS-CoV-2 recent reports of reinfection have raised critical questions on whether and how well a first infection protects against reinfection.