tetano
Editor, Senior Moderator
Rev Med Virol
. 2023 Sep 27;e2481.
doi: 10.1002/rmv.2481. Online ahead of print. Modulation of various host cellular machinery during COVID-19 infection
Shivani Malvankar[SUP] 1 [/SUP], Anjali Singh[SUP] 1 [/SUP], Y S Ravi Kumar[SUP] 2 [/SUP], Swetangini Sahu[SUP] 1 [/SUP], Megha Shah[SUP] 1 [/SUP], Yamini Murghai[SUP] 1 [/SUP], Mahendra Seervi[SUP] 1 [/SUP], Rupesh K Srivastava[SUP] 1 [/SUP], Bhupendra Verma[SUP] 1 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) emerged in December 2019, causing a range of respiratory infections from mild to severe. This resulted in the ongoing global COVID-19 pandemic, which has had a significant impact on public health. The World Health Organization declared COVID-19 as a global pandemic in March 2020. Viruses are intracellular pathogens that rely on the host's machinery to establish a successful infection. They exploit the gene expression machinery of host cells to facilitate their own replication. Gaining a better understanding of gene expression modulation in SARS-CoV2 is crucial for designing and developing effective antiviral strategies. Efforts are currently underway to understand the molecular-level interaction between the host and the pathogen. In this review, we describe how SARS-CoV2 infection modulates gene expression by interfering with cellular processes, including transcription, post-transcription, translation, post-translation, epigenetic modifications as well as processing and degradation pathways. Additionally, we emphasise the therapeutic implications of these findings in the development of new therapies to treat SARS-CoV2 infection.
Keywords: COVID-19; SARS-COV2; post-transcriptional modification; stress granules; transcription; translation.
. 2023 Sep 27;e2481.
doi: 10.1002/rmv.2481. Online ahead of print. Modulation of various host cellular machinery during COVID-19 infection
Shivani Malvankar[SUP] 1 [/SUP], Anjali Singh[SUP] 1 [/SUP], Y S Ravi Kumar[SUP] 2 [/SUP], Swetangini Sahu[SUP] 1 [/SUP], Megha Shah[SUP] 1 [/SUP], Yamini Murghai[SUP] 1 [/SUP], Mahendra Seervi[SUP] 1 [/SUP], Rupesh K Srivastava[SUP] 1 [/SUP], Bhupendra Verma[SUP] 1 [/SUP]
Affiliations
- PMID: 37758688
- DOI: 10.1002/rmv.2481
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) emerged in December 2019, causing a range of respiratory infections from mild to severe. This resulted in the ongoing global COVID-19 pandemic, which has had a significant impact on public health. The World Health Organization declared COVID-19 as a global pandemic in March 2020. Viruses are intracellular pathogens that rely on the host's machinery to establish a successful infection. They exploit the gene expression machinery of host cells to facilitate their own replication. Gaining a better understanding of gene expression modulation in SARS-CoV2 is crucial for designing and developing effective antiviral strategies. Efforts are currently underway to understand the molecular-level interaction between the host and the pathogen. In this review, we describe how SARS-CoV2 infection modulates gene expression by interfering with cellular processes, including transcription, post-transcription, translation, post-translation, epigenetic modifications as well as processing and degradation pathways. Additionally, we emphasise the therapeutic implications of these findings in the development of new therapies to treat SARS-CoV2 infection.
Keywords: COVID-19; SARS-COV2; post-transcriptional modification; stress granules; transcription; translation.