tetano
Editor, Senior Moderator
Rev Med Virol
. 2020 Sep 23.
doi: 10.1002/rmv.2174. Online ahead of print.
Severe acute respiratory syndrome-coronavirus-2: Current advances in therapeutic targets and drug development
Sakthivel Suganya[SUP] 1 2 [/SUP], Suresh Divya[SUP] 3 4 [/SUP], Madasamy Parani[SUP] 4 [/SUP]
Affiliations
Abstract
The current pandemic of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has quickly emerged as a global health concern with government bodies worldwide taking drastic control measures. Understanding the virology of SARS-CoV-2, its molecular mechanisms, and its pathogenesis are required for a targeted therapeutic approach. In this review, we highlight the current molecular and drug advances that target SARS-CoV-2 at the genome level. We also summarize studies that therapeutically target the host angiotensin-converting enzyme 2 and proteases. Finally, we summarize antibody-mediated therapeutic approaches, as well as recent trends in vaccine development. Hence, the purpose of this study is to investigate different molecular targets in SARS-CoV-2 pathogenesis and their usefulness in developing strategies for drug development.
Keywords: ACE2; SARS-CoV-2; TMPRSS2; antibodies; vaccine development; virus.
. 2020 Sep 23.
doi: 10.1002/rmv.2174. Online ahead of print.
Severe acute respiratory syndrome-coronavirus-2: Current advances in therapeutic targets and drug development
Sakthivel Suganya[SUP] 1 2 [/SUP], Suresh Divya[SUP] 3 4 [/SUP], Madasamy Parani[SUP] 4 [/SUP]
Affiliations
- PMID: 32965078
- DOI: 10.1002/rmv.2174
Abstract
The current pandemic of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has quickly emerged as a global health concern with government bodies worldwide taking drastic control measures. Understanding the virology of SARS-CoV-2, its molecular mechanisms, and its pathogenesis are required for a targeted therapeutic approach. In this review, we highlight the current molecular and drug advances that target SARS-CoV-2 at the genome level. We also summarize studies that therapeutically target the host angiotensin-converting enzyme 2 and proteases. Finally, we summarize antibody-mediated therapeutic approaches, as well as recent trends in vaccine development. Hence, the purpose of this study is to investigate different molecular targets in SARS-CoV-2 pathogenesis and their usefulness in developing strategies for drug development.
Keywords: ACE2; SARS-CoV-2; TMPRSS2; antibodies; vaccine development; virus.