tetano
Editor, Senior Moderator
Rev Port Cardiol
. 2022 Apr 29.
doi: 10.1016/j.repc.2021.05.016. Online ahead of print.
The predictive value of epicardial fat volume for clinical severity of COVID-19
[Article in Portuguese]
Mehmet Akif Erdöl[SUP] 1 [/SUP], Fatma Civelek Eser[SUP] 2 [/SUP], Abdullah Nabi Aslan[SUP] 1 [/SUP], Mehmet Erdoğan[SUP] 1 [/SUP], Adalet Altunsoy Aypak[SUP] 2 [/SUP], Muhammed Said Beşler[SUP] 3 [/SUP], Ayşe Kaya Kalem[SUP] 2 [/SUP], Ahmet Göktuğ Ertem[SUP] 1 [/SUP], Hatice Rahmet Güner[SUP] 2 [/SUP]
Affiliations
Abstract
in English, Spanish
Introduction: Epicardial adipose tissue serves as a source of inflammatory cytokines and mediators. Cytokine storm is an important cause of morbidity and mortality in coronavirus disease 2019 (COVID-19).
Objectives: To investigate the association between epicardial fat volume (EFV), inflammatory biomarkers and clinical severity of COVID-19.
Methods: This retrospective study included 101 patients who were infected with COVID-19. Serum inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT) and ferritin levels were measured. Computed tomography images were analyzed and semi-automated measurements for EFV were obtained. The primary composite endpoint was admission to the intensive care unit (ICU) or death.
Results: The primary composite endpoint occurred in 25.1% (n=26) of patients (mean age 64.8±14.8 years, 14 male). A total of 10 patients died. EFV, CRP, PCT, ferritin and IL-6 levels were significantly higher in ICU patients. Moreover, a positive correlation was determined between EFV and CRP (r: 0.494, p<0.001), PCT (r: 0.287, p=0.005), ferritin (r: 0.265, p=0.01) and IL-6 (r: 0.311, p=0.005). On receiver operating characteristic analysis, patients with EFV >102 cm[SUP]3[/SUP] were more likely to have severe complications. In multivariate logistic regression analysis, EFV independently predicted admission to the ICU at a significant level (OR: 1.02, 95% CI: 1.01-1.03, p=0.025).
Conclusion: EFV and serum CRP, IL-6, PCT and ferritin levels can effectively assess disease severity and predict the outcome in patients with COVID-19. EFV is an independent predictor of admission to the ICU in hospitalized COVID-19 patients.
Keywords: C-reactive protein; COVID-19; Computed tomography; Epicardial fat volume; Interleukin-6; Prognosis.
. 2022 Apr 29.
doi: 10.1016/j.repc.2021.05.016. Online ahead of print.
The predictive value of epicardial fat volume for clinical severity of COVID-19
[Article in Portuguese]
Mehmet Akif Erdöl[SUP] 1 [/SUP], Fatma Civelek Eser[SUP] 2 [/SUP], Abdullah Nabi Aslan[SUP] 1 [/SUP], Mehmet Erdoğan[SUP] 1 [/SUP], Adalet Altunsoy Aypak[SUP] 2 [/SUP], Muhammed Said Beşler[SUP] 3 [/SUP], Ayşe Kaya Kalem[SUP] 2 [/SUP], Ahmet Göktuğ Ertem[SUP] 1 [/SUP], Hatice Rahmet Güner[SUP] 2 [/SUP]
Affiliations
- PMID: 35505820
- PMCID: PMC9050585
- DOI: 10.1016/j.repc.2021.05.016
Abstract
in English, Spanish
Introduction: Epicardial adipose tissue serves as a source of inflammatory cytokines and mediators. Cytokine storm is an important cause of morbidity and mortality in coronavirus disease 2019 (COVID-19).
Objectives: To investigate the association between epicardial fat volume (EFV), inflammatory biomarkers and clinical severity of COVID-19.
Methods: This retrospective study included 101 patients who were infected with COVID-19. Serum inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT) and ferritin levels were measured. Computed tomography images were analyzed and semi-automated measurements for EFV were obtained. The primary composite endpoint was admission to the intensive care unit (ICU) or death.
Results: The primary composite endpoint occurred in 25.1% (n=26) of patients (mean age 64.8±14.8 years, 14 male). A total of 10 patients died. EFV, CRP, PCT, ferritin and IL-6 levels were significantly higher in ICU patients. Moreover, a positive correlation was determined between EFV and CRP (r: 0.494, p<0.001), PCT (r: 0.287, p=0.005), ferritin (r: 0.265, p=0.01) and IL-6 (r: 0.311, p=0.005). On receiver operating characteristic analysis, patients with EFV >102 cm[SUP]3[/SUP] were more likely to have severe complications. In multivariate logistic regression analysis, EFV independently predicted admission to the ICU at a significant level (OR: 1.02, 95% CI: 1.01-1.03, p=0.025).
Conclusion: EFV and serum CRP, IL-6, PCT and ferritin levels can effectively assess disease severity and predict the outcome in patients with COVID-19. EFV is an independent predictor of admission to the ICU in hospitalized COVID-19 patients.
Keywords: C-reactive protein; COVID-19; Computed tomography; Epicardial fat volume; Interleukin-6; Prognosis.