tetano
Editor, Senior Moderator
Biol Blood Marrow Transplant. 2019 Nov 1. pii: S1083-8791(19)30712-8. doi: 10.1016/j.bbmt.2019.10.030. [Epub ahead of print] [h=1]Revisiting role of vaccinations in donors, transplant recipients, immunocompromised hosts, travelers and household contacts of stem cell transplant recipients.[/h]
Majeed A[SUP]1[/SUP], Harris Z[SUP]2[/SUP], Brucks E[SUP]2[/SUP], Hinchman A[SUP]3[/SUP], Farooqui AA[SUP]4[/SUP], Tariq MJ[SUP]5[/SUP], Tamizhmani K[SUP]2[/SUP], Riaz IB[SUP]6[/SUP], McBride A[SUP]7[/SUP], Latif A[SUP]8[/SUP], Kapoor V[SUP]8[/SUP], Iftikhar R[SUP]9[/SUP], Mossad S[SUP]1[/SUP], Anwer F[SUP]10[/SUP].
[h=3]Author information[/h] 1 Department of Infectious disease, Cleveland Clinic, 9500 Euclid Ave. Cleveland, OH 44195. 2 College of medicine Department of Medicine, University of Arizona, 1515 N Campbell Ave, Tucson AZ, 85721. 3 Department of Pharmacy, University of Arizona, 1295 N. Martin, Tucson, AZ 85721. 4 King Edward Medical University, Lahore, Pakistan 54000. 5 Department of Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, 60612. 6 Department of Hematology and Oncology, Mayo Clinic, Rochester, MN, 55905. 7 Department of Pharmacy, The University of Arizona Cancer Center, Tucson, AZ 85737. 8 Department of Internal Medicine, Creighton University, Omaha, NE, 68178. 9 Armed Forces Bone Marrow Transplant Centre/ National Institute of Blood and Marrow transplant, Rawalpindi, Pakistan 46000. 10 Department of Hematology, Medical Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195. Electronic address: ANWERF@ccf.org.
[h=3]Abstract[/h] Vaccination is an effective strategy to prevent infections in immunocompromised hematopoietic stem cell transplant (HSCT) recipients. Pre-transplant vaccination of influenza, pneumococcus (PCV 7), H. Influenzae type b, diphtheria, tetanus and hepatitis B, both in donors and transplant recipients, produces high antibody titers in patients compared to recipient vaccination only. Transplant recipients are immunocompromised, live vaccines should be avoided with few exceptions. Transplant recipients should get inactive vaccinations when possible in order to prevent infection. This includes vaccination against influenza, pneumococcus, H. Influenzae type b, diphtheria, tetanus, pertussis, meningococcus, measles, mumps, rubella, polio, hepatitis A, Human Papilloma Virus (HPV) and hepatitis B. Close contacts of transplant recipients can safely get vaccinations (inactive and few live vaccines) as per their need and schedule. If transplant recipients wish to travel; they might need to get themselves vaccinated against endemic diseases which are prevalent in such areas. There is paucity of data on the role of vaccinations for patients receiving novel immunotherapy such as bispecific antibodies and chimeric antigen receptor T cells despite data on prolonged B cell depletion and higher risk of opportunistic infections.
Copyright ? 2019. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Allogeneic; Autologous; Hematopoietic Stem Cell Transplantation; Infection prophylaxis; Traveler; Vaccination
PMID: 31682981 DOI: 10.1016/j.bbmt.2019.10.030
Majeed A[SUP]1[/SUP], Harris Z[SUP]2[/SUP], Brucks E[SUP]2[/SUP], Hinchman A[SUP]3[/SUP], Farooqui AA[SUP]4[/SUP], Tariq MJ[SUP]5[/SUP], Tamizhmani K[SUP]2[/SUP], Riaz IB[SUP]6[/SUP], McBride A[SUP]7[/SUP], Latif A[SUP]8[/SUP], Kapoor V[SUP]8[/SUP], Iftikhar R[SUP]9[/SUP], Mossad S[SUP]1[/SUP], Anwer F[SUP]10[/SUP].
[h=3]Author information[/h] 1 Department of Infectious disease, Cleveland Clinic, 9500 Euclid Ave. Cleveland, OH 44195. 2 College of medicine Department of Medicine, University of Arizona, 1515 N Campbell Ave, Tucson AZ, 85721. 3 Department of Pharmacy, University of Arizona, 1295 N. Martin, Tucson, AZ 85721. 4 King Edward Medical University, Lahore, Pakistan 54000. 5 Department of Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, 60612. 6 Department of Hematology and Oncology, Mayo Clinic, Rochester, MN, 55905. 7 Department of Pharmacy, The University of Arizona Cancer Center, Tucson, AZ 85737. 8 Department of Internal Medicine, Creighton University, Omaha, NE, 68178. 9 Armed Forces Bone Marrow Transplant Centre/ National Institute of Blood and Marrow transplant, Rawalpindi, Pakistan 46000. 10 Department of Hematology, Medical Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195. Electronic address: ANWERF@ccf.org.
[h=3]Abstract[/h] Vaccination is an effective strategy to prevent infections in immunocompromised hematopoietic stem cell transplant (HSCT) recipients. Pre-transplant vaccination of influenza, pneumococcus (PCV 7), H. Influenzae type b, diphtheria, tetanus and hepatitis B, both in donors and transplant recipients, produces high antibody titers in patients compared to recipient vaccination only. Transplant recipients are immunocompromised, live vaccines should be avoided with few exceptions. Transplant recipients should get inactive vaccinations when possible in order to prevent infection. This includes vaccination against influenza, pneumococcus, H. Influenzae type b, diphtheria, tetanus, pertussis, meningococcus, measles, mumps, rubella, polio, hepatitis A, Human Papilloma Virus (HPV) and hepatitis B. Close contacts of transplant recipients can safely get vaccinations (inactive and few live vaccines) as per their need and schedule. If transplant recipients wish to travel; they might need to get themselves vaccinated against endemic diseases which are prevalent in such areas. There is paucity of data on the role of vaccinations for patients receiving novel immunotherapy such as bispecific antibodies and chimeric antigen receptor T cells despite data on prolonged B cell depletion and higher risk of opportunistic infections.
Copyright ? 2019. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Allogeneic; Autologous; Hematopoietic Stem Cell Transplantation; Infection prophylaxis; Traveler; Vaccination
PMID: 31682981 DOI: 10.1016/j.bbmt.2019.10.030