tetano
Editor, Senior Moderator
Rheum Dis Clin North Am
. 2023 Aug;49(3):647-659.
doi: 10.1016/j.rdc.2023.03.002. Epub 2023 Mar 17. Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: Common Inflammatory Pathways of Two Distinct Diseases
Magali Noval Rivas[SUP] 1 [/SUP], Moshe Arditi[SUP] 2 [/SUP]
Affiliations
Multisystem inflammatory syndrome in children (MIS-C) is a delayed postinflammatory disorder associated with the previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially, MIS-C was described as highly similar to Kawasaki disease (KD), a pediatric febrile systemic vasculitis that can lead to the development of coronary artery aneurysms (CAAs). While KD and MIS-C are both inflammatory disorders, the 2 entities differ in their epidemiological, clinical, immunological, and pathological features. MIS-C clinical and laboratory characteristics are more closely related to toxic shock syndrome (TSS) than KD, which informs the understanding of pathogenesis and potential therapeutic approaches.
Keywords: Kawasaki disease; Multisystem inflammatory syndrome in children; SARS-CoV-2; Superantigen; Superantigen-like motif; Toxic shock syndrome.
. 2023 Aug;49(3):647-659.
doi: 10.1016/j.rdc.2023.03.002. Epub 2023 Mar 17. Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: Common Inflammatory Pathways of Two Distinct Diseases
Magali Noval Rivas[SUP] 1 [/SUP], Moshe Arditi[SUP] 2 [/SUP]
Affiliations
- PMID: 37331738
- DOI: 10.1016/j.rdc.2023.03.002
Multisystem inflammatory syndrome in children (MIS-C) is a delayed postinflammatory disorder associated with the previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially, MIS-C was described as highly similar to Kawasaki disease (KD), a pediatric febrile systemic vasculitis that can lead to the development of coronary artery aneurysms (CAAs). While KD and MIS-C are both inflammatory disorders, the 2 entities differ in their epidemiological, clinical, immunological, and pathological features. MIS-C clinical and laboratory characteristics are more closely related to toxic shock syndrome (TSS) than KD, which informs the understanding of pathogenesis and potential therapeutic approaches.
Keywords: Kawasaki disease; Multisystem inflammatory syndrome in children; SARS-CoV-2; Superantigen; Superantigen-like motif; Toxic shock syndrome.