tetano
Editor, Senior Moderator
Rheum Dis Clin North Am
. 2025 Feb;51(1):15-28.
doi: 10.1016/j.rdc.2024.08.003. Epub 2024 Oct 11. The Burden of Post-Acute Sequelae of Coronavirus Disease 2019 in Individuals with Rheumatic Diseases
Shruthi Srivatsan[SUP] 1 [/SUP], Naomi J Patel[SUP] 2 [/SUP]
Affiliations
The long-term impacts of coronavirus disease 2019 (COVID-19), or post-acute sequelae of COVID-19 (PASC), are especially pertinent for individuals with systemic autoimmune rheumatic diseases, who are at higher risk of developing COVID-19 infection, complications of acute infection, and possibly PASC. Severity of acute COVID-19 infection, female sex, comorbidities, and immunosuppressive medications impact the risk of PASC in this population. The etiology of PASC remains poorly defined, and the diagnosis is clinical, with symptoms that can overlap with those of rheumatic diseases. A better understanding of the physiologic mechanisms could help to more clearly define PASC and to guide the development of targeted treatments.
Keywords: COVID-19; Immunosuppression; Infection; Post-acute sequelae; Rheumatic disease.
. 2025 Feb;51(1):15-28.
doi: 10.1016/j.rdc.2024.08.003. Epub 2024 Oct 11. The Burden of Post-Acute Sequelae of Coronavirus Disease 2019 in Individuals with Rheumatic Diseases
Shruthi Srivatsan[SUP] 1 [/SUP], Naomi J Patel[SUP] 2 [/SUP]
Affiliations
- PMID: 39550103
- DOI: 10.1016/j.rdc.2024.08.003
The long-term impacts of coronavirus disease 2019 (COVID-19), or post-acute sequelae of COVID-19 (PASC), are especially pertinent for individuals with systemic autoimmune rheumatic diseases, who are at higher risk of developing COVID-19 infection, complications of acute infection, and possibly PASC. Severity of acute COVID-19 infection, female sex, comorbidities, and immunosuppressive medications impact the risk of PASC in this population. The etiology of PASC remains poorly defined, and the diagnosis is clinical, with symptoms that can overlap with those of rheumatic diseases. A better understanding of the physiologic mechanisms could help to more clearly define PASC and to guide the development of targeted treatments.
Keywords: COVID-19; Immunosuppression; Infection; Post-acute sequelae; Rheumatic disease.