tetano
Editor, Senior Moderator
Rheumatol Adv Pract
. 2021 May 13;5(2):rkab031.
doi: 10.1093/rap/rkab031. eCollection 2021.
Predictors of hospitalization in patients with rheumatic disease and COVID-19 in Ireland: data from the COVID-19 global rheumatology alliance registry
Richard Conway[SUP] 1 [/SUP], Elena Nikiphorou[SUP] 2 [/SUP], Christiana A Demetriou[SUP] 3 [/SUP], Candice Low[SUP] 4 [/SUP], Kelly Leamy[SUP] 5 [/SUP], John G Ryan[SUP] 6 [/SUP], Ronan Kavanagh[SUP] 7 [/SUP], Alexander D Fraser[SUP] 8 [/SUP], John J Carey[SUP] 9 [/SUP], Paul O'Connell[SUP] 10 [/SUP], Rachael M Flood[SUP] 11 [/SUP], Ronan H Mullan[SUP] 11 [/SUP], David J Kane[SUP] 11 [/SUP], Philip C Robinson[SUP] 12 [/SUP], Jean W Liew[SUP] 13 [/SUP], Rebecca Grainger[SUP] 14 [/SUP], Geraldine M McCarthy[SUP] 5 [/SUP], COVID-19 Global Rheumatology Alliance
Affiliations
Abstract
Objectives: Given the limited data regarding the risk of hospitalization in patients with rheumatic disease and coronavirus disease 2019 (COVID-19) in Ireland, we used the COVID-19 Global Rheumatology Alliance (GRA) registry data to study outcomes and their predictors. The primary objective was to explore potential predictors of hospitalization.
Methods: We examined data on patients and their disease-related characteristics entered in the COVID-19 GRA provider registry from Ireland (from 24 March 2020 to 31 August 2020). Multivariable logistic regression was used to assess the association of demographic and clinical characteristics with hospitalization.
Results: Of 105 patients, 47 (45.6%) were hospitalized and 10 (9.5%) died. Multivariable logistic regression analysis showed that age [odds ratio (OR) = 1.06, 95% CI 1.01, 1.10], number of co-morbidities (OR = 1.93, 95% CI 1.11, 3.35) and glucocorticoid use (OR = 15.01, 95% CI 1.77, 127.16) were significantly associated with hospitalization. A diagnosis of inflammatory arthritis was associated with lower odds of hospitalization (OR = 0.09, 95% CI 0.02, 0.32).
Conclusion: Increasing age, co-morbidity burden and glucocorticoid use were associated with hospitalization, whereas a diagnosis of inflammatory arthritis was associated with lower odds of hospitalization.
Keywords: COVID-19; biologics; hospitalization; rheumatic disease.
. 2021 May 13;5(2):rkab031.
doi: 10.1093/rap/rkab031. eCollection 2021.
Predictors of hospitalization in patients with rheumatic disease and COVID-19 in Ireland: data from the COVID-19 global rheumatology alliance registry
Richard Conway[SUP] 1 [/SUP], Elena Nikiphorou[SUP] 2 [/SUP], Christiana A Demetriou[SUP] 3 [/SUP], Candice Low[SUP] 4 [/SUP], Kelly Leamy[SUP] 5 [/SUP], John G Ryan[SUP] 6 [/SUP], Ronan Kavanagh[SUP] 7 [/SUP], Alexander D Fraser[SUP] 8 [/SUP], John J Carey[SUP] 9 [/SUP], Paul O'Connell[SUP] 10 [/SUP], Rachael M Flood[SUP] 11 [/SUP], Ronan H Mullan[SUP] 11 [/SUP], David J Kane[SUP] 11 [/SUP], Philip C Robinson[SUP] 12 [/SUP], Jean W Liew[SUP] 13 [/SUP], Rebecca Grainger[SUP] 14 [/SUP], Geraldine M McCarthy[SUP] 5 [/SUP], COVID-19 Global Rheumatology Alliance
Affiliations
- PMID: 34622123
- PMCID: PMC8244588
- DOI: 10.1093/rap/rkab031
Abstract
Objectives: Given the limited data regarding the risk of hospitalization in patients with rheumatic disease and coronavirus disease 2019 (COVID-19) in Ireland, we used the COVID-19 Global Rheumatology Alliance (GRA) registry data to study outcomes and their predictors. The primary objective was to explore potential predictors of hospitalization.
Methods: We examined data on patients and their disease-related characteristics entered in the COVID-19 GRA provider registry from Ireland (from 24 March 2020 to 31 August 2020). Multivariable logistic regression was used to assess the association of demographic and clinical characteristics with hospitalization.
Results: Of 105 patients, 47 (45.6%) were hospitalized and 10 (9.5%) died. Multivariable logistic regression analysis showed that age [odds ratio (OR) = 1.06, 95% CI 1.01, 1.10], number of co-morbidities (OR = 1.93, 95% CI 1.11, 3.35) and glucocorticoid use (OR = 15.01, 95% CI 1.77, 127.16) were significantly associated with hospitalization. A diagnosis of inflammatory arthritis was associated with lower odds of hospitalization (OR = 0.09, 95% CI 0.02, 0.32).
Conclusion: Increasing age, co-morbidity burden and glucocorticoid use were associated with hospitalization, whereas a diagnosis of inflammatory arthritis was associated with lower odds of hospitalization.
Keywords: COVID-19; biologics; hospitalization; rheumatic disease.