tetano
Editor, Senior Moderator
J Infect Dis. 2018 Jul 17. doi: 10.1093/infdis/jiy443. [Epub ahead of print]
[h=1]Risk factors and attack rates of seasonal influenza infection: results of the SHIVERS seroepidemiologic cohort study.[/h] Huang QS[SUP]1[/SUP], Bandaranayake D[SUP]1[/SUP], Wood T[SUP]1[/SUP], Newbern EC[SUP]1[/SUP], Seeds R[SUP]1[/SUP], Ralston J[SUP]1[/SUP], Waite B[SUP]1[/SUP], Bissielo A[SUP]1[/SUP], Prasad N[SUP]1[/SUP], Todd A[SUP]1[/SUP], Jelley L[SUP]1[/SUP], Gunn W[SUP]1[/SUP], McNicholas A[SUP]1[/SUP], Metz T[SUP]1[/SUP], Lawrence S[SUP]2[/SUP], Collis E[SUP]2[/SUP], Retter A[SUP]2[/SUP], Wong SS[SUP]3[/SUP], Webby R[SUP]3[/SUP], Bocacao J[SUP]1[/SUP], Haubrock J[SUP]1[/SUP], Mackereth G[SUP]1[/SUP], Turner N[SUP]4[/SUP], McArdle B[SUP]4[/SUP], Cameron J[SUP]5[/SUP], Reynolds G[SUP]4[/SUP], Baker MG[SUP]6[/SUP], Grant CC[SUP]4[/SUP], McArthur C[SUP]7[/SUP], Roberts S[SUP]7[/SUP], Trenholme A[SUP]2[/SUP], Wong C[SUP]2[/SUP], Taylor S[SUP]2[/SUP], Thomas P[SUP]3[/SUP], Duque J[SUP]8[/SUP], Gross D[SUP]8[/SUP], Thompson MG[SUP]8[/SUP], Widdowson MA[SUP]8[/SUP]; SHIVERS investigation team.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of anti-haemagglutinin antibody responses have been described previously, studies examining both anti-haemagglutinin and anti-neuraminidase antibodies are lacking.
[h=4]Methods:[/h] In 2015, we conducted a sero-epidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for haemagglutinin-inhibition (HAI) or neuraminidase-inhibition (NAI) titres for seroconversion . We followed participants weekly and performed influenza PCR for those reporting influenza-like illness (ILI).
[h=4]Results:[/h] Influenza infection (either HAI or NAI seroconversion) was found in 321 (35%; 95%CI:32-38%) of 911 unvaccinated participants, of which 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza-PCR-confirmed ILI and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs. those aged ≥5 years (14% vs 4%; p<0.001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; p<0.001).
[h=4]Conclusions:[/h] Measurement of anti-neuraminidase antibodies in addition to anti- hemagglutinin antibodies may be important in capturing the true influenza infection rates.
PMID: 30016464 DOI: 10.1093/infdis/jiy443
[h=1]Risk factors and attack rates of seasonal influenza infection: results of the SHIVERS seroepidemiologic cohort study.[/h] Huang QS[SUP]1[/SUP], Bandaranayake D[SUP]1[/SUP], Wood T[SUP]1[/SUP], Newbern EC[SUP]1[/SUP], Seeds R[SUP]1[/SUP], Ralston J[SUP]1[/SUP], Waite B[SUP]1[/SUP], Bissielo A[SUP]1[/SUP], Prasad N[SUP]1[/SUP], Todd A[SUP]1[/SUP], Jelley L[SUP]1[/SUP], Gunn W[SUP]1[/SUP], McNicholas A[SUP]1[/SUP], Metz T[SUP]1[/SUP], Lawrence S[SUP]2[/SUP], Collis E[SUP]2[/SUP], Retter A[SUP]2[/SUP], Wong SS[SUP]3[/SUP], Webby R[SUP]3[/SUP], Bocacao J[SUP]1[/SUP], Haubrock J[SUP]1[/SUP], Mackereth G[SUP]1[/SUP], Turner N[SUP]4[/SUP], McArdle B[SUP]4[/SUP], Cameron J[SUP]5[/SUP], Reynolds G[SUP]4[/SUP], Baker MG[SUP]6[/SUP], Grant CC[SUP]4[/SUP], McArthur C[SUP]7[/SUP], Roberts S[SUP]7[/SUP], Trenholme A[SUP]2[/SUP], Wong C[SUP]2[/SUP], Taylor S[SUP]2[/SUP], Thomas P[SUP]3[/SUP], Duque J[SUP]8[/SUP], Gross D[SUP]8[/SUP], Thompson MG[SUP]8[/SUP], Widdowson MA[SUP]8[/SUP]; SHIVERS investigation team.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of anti-haemagglutinin antibody responses have been described previously, studies examining both anti-haemagglutinin and anti-neuraminidase antibodies are lacking.
[h=4]Methods:[/h] In 2015, we conducted a sero-epidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for haemagglutinin-inhibition (HAI) or neuraminidase-inhibition (NAI) titres for seroconversion . We followed participants weekly and performed influenza PCR for those reporting influenza-like illness (ILI).
[h=4]Results:[/h] Influenza infection (either HAI or NAI seroconversion) was found in 321 (35%; 95%CI:32-38%) of 911 unvaccinated participants, of which 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza-PCR-confirmed ILI and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs. those aged ≥5 years (14% vs 4%; p<0.001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; p<0.001).
[h=4]Conclusions:[/h] Measurement of anti-neuraminidase antibodies in addition to anti- hemagglutinin antibodies may be important in capturing the true influenza infection rates.
PMID: 30016464 DOI: 10.1093/infdis/jiy443