tetano
Editor, Senior Moderator
Bull Exp Biol Med. 2013 Oct;156(1):11-4.
Role of Matrix Metalloproteinases and Their Inhibitor in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H5N1 A/GOOSE/Krasnoozerskoye/627/05 Virus.
[Article in English, Russian]
Anikina AG, Potapova OV, Shkurupii VA, Shestopalov AM.
Source
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Vector State Research Center of Virology and Biotechnology, Novosibirsk Region, Koltsovo; Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Russia. potapova@soramn.ru.
Abstract
High levels of macrophages and fibroblasts expressing MMP-2, MMP-9, and MMP-10 against the background of progressing early fibrosis of the lungs (manifesting in an increase in volume density of type I, III, IV, and VI collagens) were found in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. Progressing fibrosis of the lungs in infected mice was associated with imbalance of collagen synthesis and degradation processes conjugated with high levels of macrophages and fibroblasts expressing TIMP-2.
PMID:
24319704
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24319704
Role of Matrix Metalloproteinases and Their Inhibitor in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H5N1 A/GOOSE/Krasnoozerskoye/627/05 Virus.
[Article in English, Russian]
Anikina AG, Potapova OV, Shkurupii VA, Shestopalov AM.
Source
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Vector State Research Center of Virology and Biotechnology, Novosibirsk Region, Koltsovo; Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Russia. potapova@soramn.ru.
Abstract
High levels of macrophages and fibroblasts expressing MMP-2, MMP-9, and MMP-10 against the background of progressing early fibrosis of the lungs (manifesting in an increase in volume density of type I, III, IV, and VI collagens) were found in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. Progressing fibrosis of the lungs in infected mice was associated with imbalance of collagen synthesis and degradation processes conjugated with high levels of macrophages and fibroblasts expressing TIMP-2.
PMID:
24319704
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24319704