tetano
Editor, Senior Moderator
J Infect Dis. 2012 Jul 16. [Epub ahead of print]
Safety and Immune Responses in Children after Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations.
Frey SE, Bernstein DI, Gerber MA, Keyserling HL, Munoz FM, Winokur PL, Turley CB, Rupp RE, Hill H, Wolff M, Noah DL, Ross AC, Cress G, Belshe RB.
Source
Saint Louis University School of Medicine.
Abstract
Background. Administering two separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 and seasonal trivalent inactivated (TIV) influenza vaccines (split virion) given sequentially or concurrently in previously vaccinated children.Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in one of 4 combinations. Injections were given at 21 day intervals and sera for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored.Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, one dose of 2009 H1N1 and one dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1.Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 were required to achieve a protective immune response in children <10 years of age.
PMID:
22802432
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22802432
Safety and Immune Responses in Children after Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations.
Frey SE, Bernstein DI, Gerber MA, Keyserling HL, Munoz FM, Winokur PL, Turley CB, Rupp RE, Hill H, Wolff M, Noah DL, Ross AC, Cress G, Belshe RB.
Source
Saint Louis University School of Medicine.
Abstract
Background. Administering two separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 and seasonal trivalent inactivated (TIV) influenza vaccines (split virion) given sequentially or concurrently in previously vaccinated children.Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in one of 4 combinations. Injections were given at 21 day intervals and sera for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored.Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, one dose of 2009 H1N1 and one dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1.Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 were required to achieve a protective immune response in children <10 years of age.
PMID:
22802432
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22802432