tetano
Editor, Senior Moderator
SAGE Open Med Case Rep
. 2024 Feb 20:12:2050313X241233432.
doi: 10.1177/2050313X241233432. eCollection 2024. A case report of QTc prolongation: Drug induced or myocarditis in Severe Acute Respiratory Syndrome Coronavirus 2
Mahboobeh Gholipour[SUP] 1 [/SUP], Pirooz Samidoost[SUP] 2 [/SUP], Mani Moayerifar[SUP] 2 [/SUP], Golshan Ghasemzadeh[SUP] 3 [/SUP]
Affiliations
Remdesivir is a nucleotide prodrug of an adenosine analog. It binds to the viral Ribonucleic Acid (RNA)-dependent RNA polymerase and inhibits viral replication by terminating RNA transcription prematurely. Remdesivir has demonstrated in vitro and in vivo activity against Severe Acute Respiratory Syndrome Coronavirus 2; it also acts in vitro neutralization activity against the Omicron variant and its subvariants. We reported a 54-years-old woman admitted with Coronavirus disease 2019. Considering to require a high fraction of inspired oxygen therapy (⩾0.6) and based on lung high resolution computed tomography, Remdesivir therapy was ordered for 5 days. She experienced palpitations and dizziness 2 days after starting Remdesivir therapy. Her QTc interval was prolonged on the electrocardiogram without any significant electrolyte abnormalities or concomitant use of medications. Although the cardiac side effects of Remdesivir therapy have been well documented, in a few cases reported the association between Remdesivir therapy and QTc interval prolongation. Since, QTc interval prolongation has the potential risk of sudden cardiac death, the clinicians should be aware of mentioned association and check electrocardiogram daily, as well as other laboratory exams.
Keywords: Remdesivir; SARS-CoV-2; electrocardiography; long QT syndrome.
. 2024 Feb 20:12:2050313X241233432.
doi: 10.1177/2050313X241233432. eCollection 2024. A case report of QTc prolongation: Drug induced or myocarditis in Severe Acute Respiratory Syndrome Coronavirus 2
Mahboobeh Gholipour[SUP] 1 [/SUP], Pirooz Samidoost[SUP] 2 [/SUP], Mani Moayerifar[SUP] 2 [/SUP], Golshan Ghasemzadeh[SUP] 3 [/SUP]
Affiliations
- PMID: 38384983
- PMCID: PMC10880539
- DOI: 10.1177/2050313X241233432
Remdesivir is a nucleotide prodrug of an adenosine analog. It binds to the viral Ribonucleic Acid (RNA)-dependent RNA polymerase and inhibits viral replication by terminating RNA transcription prematurely. Remdesivir has demonstrated in vitro and in vivo activity against Severe Acute Respiratory Syndrome Coronavirus 2; it also acts in vitro neutralization activity against the Omicron variant and its subvariants. We reported a 54-years-old woman admitted with Coronavirus disease 2019. Considering to require a high fraction of inspired oxygen therapy (⩾0.6) and based on lung high resolution computed tomography, Remdesivir therapy was ordered for 5 days. She experienced palpitations and dizziness 2 days after starting Remdesivir therapy. Her QTc interval was prolonged on the electrocardiogram without any significant electrolyte abnormalities or concomitant use of medications. Although the cardiac side effects of Remdesivir therapy have been well documented, in a few cases reported the association between Remdesivir therapy and QTc interval prolongation. Since, QTc interval prolongation has the potential risk of sudden cardiac death, the clinicians should be aware of mentioned association and check electrocardiogram daily, as well as other laboratory exams.
Keywords: Remdesivir; SARS-CoV-2; electrocardiography; long QT syndrome.