tetano
Editor, Senior Moderator
Saudi J Biol Sci
. 2020 May 15.
doi: 10.1016/j.sjbs.2020.05.024. Online ahead of print.
Current Scenario of COVID-19 in Pediatric Age Group and Physiology of Immune and Thymus Response
Suriya Rehman[SUP] 1 [/SUP], Tariq Majeed[SUP] 2 [/SUP], Mohammad Azam Ansari[SUP] 1 [/SUP], Uzma Ali[SUP] 3 [/SUP], Hussein Sabit[SUP] 4 [/SUP], Ebtesam A Al-Suhaimi[SUP] 5 [/SUP]
Affiliations
Abstract
COVID-19 pandemic caused by SARS-CoV-2, continues to manifest with severe acute respiratory syndrome among the adults, however, it offers a convincing indication of less severity and fatality in pediatric age group (0-18 years). The current trend suggests that children may get infected but are less symptomatic with less fatality, which is concordant to earlier epidemic outbreaks of SARS-CoV and MERS-CoV, in 2002 and 2012, respectively. According to the available data, children appear to be at lower risk for COVID-19, as adults constitute for maximum number of the confirmed cases (308,592) and deaths (13,069) as on 22[SUP]nd[/SUP] March (https://www.worldometers.info/coronavirus). However, rapid publications and information of the adult patients with COVID-19 is in progress and published, on the contrary, almost no comprehensive data or discussion about the COVID-19 in children is available. Therefore, in this review, we outline the epidemiology, clinical symptoms, diagnosis, treatment, prevention, possible immune response and role of thymus in children to combat the COVID-19 outbreak.
Keywords: ARDS, Acute Respiratory Distress Syndrome; COVID-19; COVID-19, Coronavirus Disease-2019; Children; Coronaviruses; Immunity; MERS-CoV, Middle East Respiratory Syndrome Coronavirus; Pandemic; SARS-CoV, Severe Acute Respiratory Syndrome Coronavirus; Thymus; WHO, World Health Organization; pp1ab, Polyprotein 1ab.
. 2020 May 15.
doi: 10.1016/j.sjbs.2020.05.024. Online ahead of print.
Current Scenario of COVID-19 in Pediatric Age Group and Physiology of Immune and Thymus Response
Suriya Rehman[SUP] 1 [/SUP], Tariq Majeed[SUP] 2 [/SUP], Mohammad Azam Ansari[SUP] 1 [/SUP], Uzma Ali[SUP] 3 [/SUP], Hussein Sabit[SUP] 4 [/SUP], Ebtesam A Al-Suhaimi[SUP] 5 [/SUP]
Affiliations
- PMID: 32425651
- PMCID: PMC7227606
- DOI: 10.1016/j.sjbs.2020.05.024
Abstract
COVID-19 pandemic caused by SARS-CoV-2, continues to manifest with severe acute respiratory syndrome among the adults, however, it offers a convincing indication of less severity and fatality in pediatric age group (0-18 years). The current trend suggests that children may get infected but are less symptomatic with less fatality, which is concordant to earlier epidemic outbreaks of SARS-CoV and MERS-CoV, in 2002 and 2012, respectively. According to the available data, children appear to be at lower risk for COVID-19, as adults constitute for maximum number of the confirmed cases (308,592) and deaths (13,069) as on 22[SUP]nd[/SUP] March (https://www.worldometers.info/coronavirus). However, rapid publications and information of the adult patients with COVID-19 is in progress and published, on the contrary, almost no comprehensive data or discussion about the COVID-19 in children is available. Therefore, in this review, we outline the epidemiology, clinical symptoms, diagnosis, treatment, prevention, possible immune response and role of thymus in children to combat the COVID-19 outbreak.
Keywords: ARDS, Acute Respiratory Distress Syndrome; COVID-19; COVID-19, Coronavirus Disease-2019; Children; Coronaviruses; Immunity; MERS-CoV, Middle East Respiratory Syndrome Coronavirus; Pandemic; SARS-CoV, Severe Acute Respiratory Syndrome Coronavirus; Thymus; WHO, World Health Organization; pp1ab, Polyprotein 1ab.