tetano
Editor, Senior Moderator
Scand J Immunol
. 2021 Oct 9;e13108.
doi: 10.1111/sji.13108. Online ahead of print.
Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19
Ayca Emsen[SUP] 1 [/SUP], Sua Sumer[SUP] 2 [/SUP], Baykal Tulek[SUP] 3 [/SUP], Hilal Cizmecioglu[SUP] 4 [/SUP], HusamettinVatansev[SUP] 5 [/SUP], Mevlut Hakan Goktepe[SUP] 4 [/SUP], Fikret Kanat[SUP] 3 [/SUP], Yavuz Koksal[SUP] 6 [/SUP], Ugur Arslan[SUP] 7 [/SUP], Hasibe Artac[SUP] 1 [/SUP]
Affiliations
Abstract
The novel coronavirus disease 2019 (COVID-19) remains a global health emergency, and understanding the interactions between the virus and host immune responses is crucial to preventing its lethal effects. The expansion of myeloid-derived suppressor cells (MDSCs) in COVID-19, thereby suppressing immune responses, has been described as responsible for the severity of the disease, but the correlation between MDSC subsets and COVID-19 severity remains elusive. Therefore, we classified patients according to clinical and laboratory findings - aiming to investigate the relationship between MDSC subsets and laboratory findings such as high C-reactive protein, ferritin and lactate dehydrogenase levels, which indicate the severity of the disease. Forty-one patients with COVID-19 (26 mild and 15 severe; mean age of 49.7 ± 15 years) and 26 healthy controls were included in this study. MDSCs were grouped into two major subsets - polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs - by flow cytometric immunophenotyping, and PMN-MDSCs were defined as mature and immature, according to CD16 expressions, for the first time in COVID-19. Total MDSCs, PMN-MDSCs, mature PMN-MDSCs and monocytic MDSCs were significantly higher in patients with COVID-19 compared to the healthy controls (P < 0.05). Only PMN-MDSCs and their immature PMN-MDSC subsets were higher in the severe subgroup than in the mild subgroup. In addition, a significant correlation was found between C-reactive protein, ferritin and lactate dehydrogenase levels and MDSCs in patients with COVID-19. These findings suggest that MDSCs play a role in the pathogenesis of COVID-19, while PMN-MDSCs, especially immature PMN-MDSCs, are associated with the severity of the disease.
Keywords: COVID-19; MDSC subsets and acute-phase reactants.
. 2021 Oct 9;e13108.
doi: 10.1111/sji.13108. Online ahead of print.
Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19
Ayca Emsen[SUP] 1 [/SUP], Sua Sumer[SUP] 2 [/SUP], Baykal Tulek[SUP] 3 [/SUP], Hilal Cizmecioglu[SUP] 4 [/SUP], HusamettinVatansev[SUP] 5 [/SUP], Mevlut Hakan Goktepe[SUP] 4 [/SUP], Fikret Kanat[SUP] 3 [/SUP], Yavuz Koksal[SUP] 6 [/SUP], Ugur Arslan[SUP] 7 [/SUP], Hasibe Artac[SUP] 1 [/SUP]
Affiliations
- PMID: 34625989
- DOI: 10.1111/sji.13108
Abstract
The novel coronavirus disease 2019 (COVID-19) remains a global health emergency, and understanding the interactions between the virus and host immune responses is crucial to preventing its lethal effects. The expansion of myeloid-derived suppressor cells (MDSCs) in COVID-19, thereby suppressing immune responses, has been described as responsible for the severity of the disease, but the correlation between MDSC subsets and COVID-19 severity remains elusive. Therefore, we classified patients according to clinical and laboratory findings - aiming to investigate the relationship between MDSC subsets and laboratory findings such as high C-reactive protein, ferritin and lactate dehydrogenase levels, which indicate the severity of the disease. Forty-one patients with COVID-19 (26 mild and 15 severe; mean age of 49.7 ± 15 years) and 26 healthy controls were included in this study. MDSCs were grouped into two major subsets - polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs - by flow cytometric immunophenotyping, and PMN-MDSCs were defined as mature and immature, according to CD16 expressions, for the first time in COVID-19. Total MDSCs, PMN-MDSCs, mature PMN-MDSCs and monocytic MDSCs were significantly higher in patients with COVID-19 compared to the healthy controls (P < 0.05). Only PMN-MDSCs and their immature PMN-MDSC subsets were higher in the severe subgroup than in the mild subgroup. In addition, a significant correlation was found between C-reactive protein, ferritin and lactate dehydrogenase levels and MDSCs in patients with COVID-19. These findings suggest that MDSCs play a role in the pathogenesis of COVID-19, while PMN-MDSCs, especially immature PMN-MDSCs, are associated with the severity of the disease.
Keywords: COVID-19; MDSC subsets and acute-phase reactants.