tetano
Editor, Senior Moderator
Scand J Immunol
. 2023 Aug;98(2):e13275.
doi: 10.1111/sji.13275. Epub 2023 May 7. Role of toll-like receptors in the pathogenesis of COVID-19: Current and future perspectives
Ming-Yan Yang[SUP] 1 [/SUP], Mei-Hua Zheng[SUP] 1 [/SUP], Xiang-Ting Meng[SUP] 1 [/SUP], Le-Wei Ma[SUP] 2 [/SUP], Hai-Yue Liang[SUP] 3 [/SUP], Hua-Ying Fan[SUP] 1 [/SUP]
Affiliations
The coronavirus disease 2019 (COVID-19) pandemic underlines a persistent threat of respiratory tract infectious diseases and warrants preparedness for a rapid response. At present, COVID-19 has had a serious social impact and imposed a heavy global burden on public health. The exact pathogenesis of COVID-19 has not been fully elucidated. Since the outbreak of COVID-19, a renewed attention has been brought to Toll-like receptors (TLRs). Available data and new findings have demonstrated that the interaction of human TLRs and SARS-CoV-2 is a vital mediator of COVID-19 immunopathogenesis. TLRs such as TLR2, 4, 7 and 8 are potentially important in viral combat and activation of immunity in patients with COVID-19. Therapeutics targeting TLRs are currently considered promising options against the pandemic. A number of TLR-targeting immunotherapeutics are now being investigated in preclinical studies and different phases of clinical trials. In addition, innovative vaccines based on TLRs under development could be a promising approach for building a new generation of vaccines to solve the current challenges. In this review, we summarize recent progress in the role of TLRs in COVID-19, focusing the new candidate drugs targeting TLRs, the current technology and potential paths forward for employing TLR agonists as vaccine adjuvants.
Keywords: COVID‐19; SARS‐CoV‐2; toll‐like receptors; vaccine.
. 2023 Aug;98(2):e13275.
doi: 10.1111/sji.13275. Epub 2023 May 7. Role of toll-like receptors in the pathogenesis of COVID-19: Current and future perspectives
Ming-Yan Yang[SUP] 1 [/SUP], Mei-Hua Zheng[SUP] 1 [/SUP], Xiang-Ting Meng[SUP] 1 [/SUP], Le-Wei Ma[SUP] 2 [/SUP], Hai-Yue Liang[SUP] 3 [/SUP], Hua-Ying Fan[SUP] 1 [/SUP]
Affiliations
- PMID: 38441378
- DOI: 10.1111/sji.13275
The coronavirus disease 2019 (COVID-19) pandemic underlines a persistent threat of respiratory tract infectious diseases and warrants preparedness for a rapid response. At present, COVID-19 has had a serious social impact and imposed a heavy global burden on public health. The exact pathogenesis of COVID-19 has not been fully elucidated. Since the outbreak of COVID-19, a renewed attention has been brought to Toll-like receptors (TLRs). Available data and new findings have demonstrated that the interaction of human TLRs and SARS-CoV-2 is a vital mediator of COVID-19 immunopathogenesis. TLRs such as TLR2, 4, 7 and 8 are potentially important in viral combat and activation of immunity in patients with COVID-19. Therapeutics targeting TLRs are currently considered promising options against the pandemic. A number of TLR-targeting immunotherapeutics are now being investigated in preclinical studies and different phases of clinical trials. In addition, innovative vaccines based on TLRs under development could be a promising approach for building a new generation of vaccines to solve the current challenges. In this review, we summarize recent progress in the role of TLRs in COVID-19, focusing the new candidate drugs targeting TLRs, the current technology and potential paths forward for employing TLR agonists as vaccine adjuvants.
Keywords: COVID‐19; SARS‐CoV‐2; toll‐like receptors; vaccine.